ReviewThe Journal of clinical investigation2005
Regeneration of the pancreatic beta cell.
Review in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 98 citations in OpenAlex.
- In Vivo Differentiation of Endogenous Bone Marrow-Derived Cells into Insulin-Producing Cells Using Four Soluble Factors.Diabetes & metabolism journal · 2025Article
- Polymeric Materials, Advances and Applications in Tissue Engineering: A Review.Bioengineering (Basel, Switzerland) · 2023Review
- Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice.Therapeutic advances in endocrinology and metabolism · 2021Review
- Wdr13 and streptozotocin-induced diabetes.Nutrition & diabetes · 2018Article
- FGF-2b and h-PL Transform Duct and Non-Endocrine Human Pancreatic Cells into Endocrine Insulin Secreting Cells by Modulating Differentiating Genes.International journal of molecular sciences · 2017Article
- Garlic and Resveratrol Attenuate Diabetic Complications, Loss of β-Cells, Pancreatic and Hepatic Oxidative Stress in Streptozotocin-Induced Diabetic Rats.Frontiers in pharmacology · 2016Article
- Enterovirus and type 1 diabetes: What is the matter?World journal of diabetes · 2015Review
- Compromised central tolerance of ICA69 induces multiple organ autoimmunity.Journal of autoimmunity · 2014Article
- Acinar-to-ductal metaplasia induced by adenovirus-mediated pancreatic expression of Isl1.PloS one · 2012Article
- Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine.Transplant international : official journal of the European Society for Organ Transplantation · 2011Article
- Article
- P21cip-overexpression in the mouse beta cells leads to the improved recovery from streptozotocin-induced diabetes.PloS one · 2009Article
- Cellular origins of beta-cell regeneration: a legacy view of historical controversies.Journal of internal medicine · 2009Review
- Recovery of endogenous beta-cell function in nonhuman primates after chemical diabetes induction and islet transplantation.Diabetes · 2009Article
- Article
- Pancreatic endocrine and exocrine cell ontogeny from renal capsule transplanted embryonic stem cells in streptozocin-injured mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- The current status of islet transplantation and its perspectives.The review of diabetic studies : RDS · 2008Article
- A matching algorithm for the distribution of human pancreatic islets.Computational statistics & data analysis · 2007Article
- Adult stem or progenitor cells in treatment for type 1 diabetes: current progress.Canadian journal of surgery. Journal canadien de chirurgie · 2007Review
- Mechanisms of action of glucagon-like peptide 1 in the pancreas.Pharmacology & therapeutics · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes is the result of an autoimmune attack against the insulin-producing beta cells of the endocrine pancreas. Current treatment for patients with type 1 diabetes typically involves a rigorous and invasive regimen of testing blood glucose levels many times a day along with subcutaneous injections of recombinant DNA-derived insulin. Islet transplantation, even with its substantially improved outcome in recent years, is still not indicated for pediatric patients. However, in light of the fact that some regenerative capabilities of the endocrine pancreas have been documented and recent research has shown that human ES cell lines can be derived in vitro, this review discusses whether it is practical or even possible to combine these lines of research to more effectively treat young diabetic patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.