Evidence map›Paper›PMID 15630409›Full record

ReviewMolecular psychiatry2005

Active zones for presynaptic plasticity in the brain.

P García-Junco-Clemente, P Linares-Clemente, R Fernández-Chacón

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Presynaptic long-term plasticity.Frontiers in synaptic neuroscience · 2013
    Review
  5. Munc13-1 is required for presynaptic long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Primary afferent NMDA receptors increase dorsal horn excitation and mediate opiate tolerance in neonatal rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

P García-Junco-ClementeDepartamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla. Avda. Sánchez-Pizjuán 4, Sevilla, Spain.
P Linares-Clemente
R Fernández-Chacón

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some of the most abundant synapses in the brain such as the synapses formed by the hippocampal mossy fibers, cerebellar parallel fibers and several types of cortical afferents express presynaptic forms of long-term potentiation (LTP), a putative cellular model for spatial, motor and fear learning. Those synapses often display presynaptic mechanisms of LTP induction, which are either NMDA receptor independent of dependent of presynaptic NMDA receptors. Recent investigations on the molecular mechanisms of neurotransmitter release modulation in short- and long-term synaptic plasticity in central synapses give a preponderant role to active zone proteins as Munc-13 and RIM1-alpha, and point toward the maturation process of synaptic vesicles prior to Ca(2+)-dependent fusion as a key regulatory step of presynaptic plasticity.

Indexed as

AnimalsBrainHumansLong-Term PotentiationMossy Fibers, HippocampalNerve Tissue ProteinsNeural PathwaysPresynaptic Terminalsrab3 GTP-Binding ProteinsReceptors, N-Methyl-D-AspartateSynaptic VesiclesNerve Tissue Proteinsrab3 GTP-Binding ProteinsReceptors, N-Methyl-D-AspartateUNC13B protein, human

Identifiers

PMID15630409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.