ArticleGenes & development2005
The FLP proteins act as regulators of chlorophyll synthesis in response to light and plastid signals in Chlamydomonas.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 67 citations in OpenAlex.
- One-helix protein 2 is not required for the synthesis of photosystem II subunit D1 in Chlamydomonas.Plant physiology · 2023Article
- Photosynthetic efficiency and transcriptome analysis ofFrontiers in plant science · 2023Article
- Post-translational regulation of metabolic checkpoints in plant tetrapyrrole biosynthesis.Journal of experimental botany · 2022Review
- Pas de Trois: An Overview of Penta-, Tetra-, and Octo-Tricopeptide Repeat Proteins FromFrontiers in plant science · 2021Review
- Characterization of Ferredoxin-Dependent Biliverdin Reductase PCYA1 Reveals the Dual Function in Retrograde Bilin Biosynthesis and Interaction With Light-Dependent Protochlorophyllide Oxidoreductase LPOR inFrontiers in plant science · 2018Article
- Bilin-Dependent Photoacclimation inThe Plant cell · 2017Article
- A Light Harvesting Complex-Like Protein in Maintenance of Photosynthetic Components inPlant physiology · 2017Article
- In silico analysis of the sequence features responsible for alternatively spliced introns in the model green alga Chlamydomonas reinhardtii.Plant molecular biology · 2017Article
- Honoring Jean-David Rochaix.Photosynthesis research · 2017Article
- CCS2, an Octatricopeptide-Repeat Protein, Is Required for Plastid CytochromeFrontiers in plant science · 2017Article
- The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase.The Journal of biological chemistry · 2015Article
- Phytochrome controls alternative splicing to mediate light responses in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The interplay of light and oxygen in the reactive oxygen stress response of Chlamydomonas reinhardtii dissected by quantitative mass spectrometry.Molecular & cellular proteomics : MCP · 2014Article
- Let there be light: regulation of gene expression in plants.RNA biology · 2014Article
- Cuscuta europaea plastid apparatus in various developmental stages: localization of THF1 protein.Plant signaling & behavior · 2013Article
- Retrograde bilin signaling enables Chlamydomonas greening and phototrophic survival.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- GUN4-porphyrin complexes bind the ChlH/GUN5 subunit of Mg-Chelatase and promote chlorophyll biosynthesis in Arabidopsis.The Plant cell · 2011Article
- Genome-wide analysis of alternative splicing in Chlamydomonas reinhardtii.BMC genomics · 2010Article
- Regulation of a glutamyl-tRNA synthetase by the heme status.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- EST assembly supported by a draft genome sequence: an analysis of the Chlamydomonas reinhardtii transcriptome.Nucleic acids research · 2007Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In photosynthetic organisms the accumulation of harmful photodynamic chlorophyll precursors is prevented because of the tight regulation of the tetrapyrrole pathway. FLU is one of the regulatory factors involved in this process in land plants. We have examined the function of a Flu-like gene (FLP) from Chlamydomonas that gives rise to two FLP transcripts through alternative splicing. These transcripts are translated into a short and a long protein that differ by only 12 amino acids but that interact differently with glutamyl-tRNA reductase, an enzyme involved in an early step of the chlorophyll biosynthetic pathway. Expression of FLPs is light-regulated at the level of RNA accumulation and splicing and is altered by mutations affecting the pathway. The relative levels of the long and short forms of FLP can be correlated with the accumulation of specific porphyrin intermediates, some of which have been implicated in a signaling chain from the chloroplast to the nucleus. Reciprocally, reduction of the FLP proteins by RNA interference leads to the accumulation of several porphyrin intermediates and to photobleaching when cells are transferred from the dark to the light. Thus the FLP proteins act as regulators of chlorophyll synthesis, and their expression is controlled by light and plastid signals.
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