ArticleJournal of bacteriology2005
Comparative genomics of Staphylococcus aureus musculoskeletal isolates.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Review
- Presence and mRNA Expression of theIndian journal of microbiology · 2024Article
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- Genomic characterization of Staphylococcus aureus from Canastra Minas Artisanal Cheeses.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- In Silico Genome-Scale Analysis of Molecular Mechanisms Contributing to the Development of a Persistent Infection with Methicillin-ResistantInternational journal of molecular sciences · 2022Article
- Dysregulation of Cell Envelope Homeostasis in Staphylococcus aureus Exposed to Solvated Lignin.Applied and environmental microbiology · 2022Article
- Staphylococcus aureus Efflux Pumps and Tolerance to Ciprofloxacin and Chlorhexidine following Induction by Mupirocin.Antimicrobial agents and chemotherapy · 2022Article
- Limiting protease production plays a key role in the pathogenesis of the divergent clinical isolates ofVirulence · 2021Article
- Staphylococcus aureus Fibronectin Binding Protein A Mediates Biofilm Development and Infection.Infection and immunity · 2020Article
- Article
- Tryptoline-based benzothiazoles re-sensitize MRSA to β-lactam antibiotics.Bioorganic & medicinal chemistry · 2019Article
- Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-ResistantACS medicinal chemistry letters · 2019Article
- Molecular prophage typing ofJournal of veterinary science · 2018Article
- Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo.Virulence · 2017Article
- Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection.PloS one · 2017Article
- The Chemical and Antibacterial Evaluation of St. John's Wort Oil Macerates Used in Kosovar Traditional Medicine.Frontiers in microbiology · 2017Article
- Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus.Infection and immunity · 2016Article
- In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams.Antimicrobial agents and chemotherapy · 2016Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
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Abstract
Much of the research aimed at defining the pathogenesis of Staphylococcus aureus has been done with a limited number of strains, most notably the 8325-4 derivative RN6390. Several lines of evidence indicate that this strain is unique by comparison to clinical isolates of S. aureus. Based on this, we have focused our efforts on two clinical isolates (UAMS-1 and UAMS-601), both of which are hypervirulent in our animal models of musculoskeletal infection. In this study, we used comparative genomic hybridization to assess the genome content of these two isolates relative to RN6390 and each of seven sequenced S. aureus isolates. Our comparisons were done by using an amplicon-based microarray from the Pathogen Functional Genomics Resource Center and an Affymetrix GeneChip that collectively represent the genomes of all seven sequenced strains. Our results confirmed that UAMS-1 and UAMS-601 share specific attributes that distinguish them from RN6390. Potentially important differences included the presence of cna and the absence of isaB, sarT, sarU, and sasG in the UAMS isolates. Among the sequenced strains, the UAMS isolates were most closely related to the dominant European clone EMRSA-16. In contrast, RN6390, NCTC 8325, and COL formed a distinct cluster that, by comparison to the other four sequenced strains (Mu50, N315, MW2, and SANGER-476), was the most distantly related to the UAMS isolates and EMRSA-16.
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