ArticleMolecular cell2005
An extended signal involved in eukaryotic -1 frameshifting operates through modification of the E site tRNA.
Article in Molecular cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (FamilyVeterinary sciences · 2024Review
- Molecular characterization of birch toti-like virus, a plant-associated member of the new family Orthototiviridae.Archives of virology · 2024Article
- Diversity in Biological Function and Mechanism of the tRNA Methyltransferase Trm10.Accounts of chemical research · 2023Article
- Article
- The life and times of a tRNA.RNA (New York, N.Y.) · 2023Review
- mRNA and tRNA modification states influence ribosome speed and frame maintenance during poly(lysine) peptide synthesis.The Journal of biological chemistry · 2022Article
- Article
- Transcription of the Envelope Protein by 1-L Protein-RNA Recognition Code Leads to Genes/Proteins That Are Relevant to the SARS-CoV-2 Life Cycle and Pathogenesis.Current issues in molecular biology · 2022Article
- Insight into genomic organization of pathogenic coronaviruses, SARS-CoV-2: Implication for emergence of new variants, laboratory diagnosis and treatment options.Frontiers in molecular medicine · 2022Review
- Characterization of Two Novel Toti-Like Viruses Co-infecting the Atlantic Blue Crab,Frontiers in microbiology · 2022Review
- Pseudouridines of tRNA Anticodon Stem-Loop Have Unexpected Role in Mutagenesis inMicroorganisms · 2020Article
- The UCSC SARS-CoV-2 Genome Browser.Nature genetics · 2020Article
- Identification of the enzymes responsible for m2,2G and acp3U formation on cytosolic tRNA from insects and plants.PloS one · 2020Article
- A Novel Totivirus Naturally Occurring in Two Different Fungal Genera.Frontiers in microbiology · 2019Article
- Review
- Molecular Characterization of Novel Totivirus-Like Double-Stranded RNAs fromFrontiers in microbiology · 2017Article
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition.Human genetics · 2016Article
- From Prebiotics to Probiotics: The Evolution and Functions of tRNA Modifications.Life (Basel, Switzerland) · 2016Review
- Viral and Cellular mRNA Translation in Coronavirus-Infected Cells.Advances in virus research · 2016Review
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By using a sensitive search program based on hidden Markov models (HMM), we identified 74 viruses carrying frameshift sites among 1500 fully sequenced virus genomes. These viruses are clustered in specific families or genera. Sequence analysis of the frameshift sites identified here, along with previously characterized sites, identified a strong bias toward the two nucleotides 5' of the shifty heptamer signal. Functional analysis in the yeast Saccharomyces cerevisiae demonstrated that high frameshifting efficiency is correlated with the presence of a Psi39 modification in the tRNA present in the E site of the ribosome at the time of frameshifting. These results demonstrate that an extended signal is involved in eukaryotic frameshifting and suggest additional interactions between tRNAs and the ribosome during decoding.
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