Evidence map›Paper›PMID 15628723›Full record

ArticleDigestive diseases and sciences

Advanced colorectal carcinomas measuring 20 mm or less exhibit markedly higher invasiveness despite their size.

Yasuhiro Kunii, Toshiki Kamano, Yuichi Tomiki, Shu Hirai, Shinji Kasamaki, Kazuhiro Sakamoto

Abstract read
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In one paragraph

Article in Digestive diseases and sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yasuhiro KuniiDepartment of Coloproctological Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Toshiki Kamano
Yuichi Tomiki
Shu Hirai
Shinji Kasamaki
Kazuhiro Sakamoto

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To analyze the biology of small (20 mm or less) advanced colorectal carcinomas (SAC), 24 cases, 22 small early colorectal carcinomas (SEC) of similar size, and 52 advanced colorectal carcinomas (AC) were studied. The proliferative (Ki-67) labeling index for SAC was 65.9+/-17.1%, significantly higher than those for SEC (30.9+/-13.7%) or AC (43.0+/-17.1%) (P < 0.01). Matrix metalloproteinase (MMP)-9 and tissue inhibitors of metalloproteinase (TIMP)-2 expressions for SAC were 62.5 and 79.2%, respectively, significantly higher than those for SEC (4.5, 13.6%) or AC (21, 33%) (P < 0.01). Small advanced carcinomas have higher invasiveness than SEC or AC and may represent a different type of cancer.

Indexed as

Cell ProliferationColorectal NeoplasmsHumansImmunohistochemistryMatrix Metalloproteinase 9Neoplasm InvasivenessTissue Inhibitor of Metalloproteinase-2Matrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-2

Identifiers

PMID15628723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.