ArticleBiophysical journal2005
GABAA receptor kinetics in the cerebellar nuclei: evidence for detection of transmitter from distant release sites.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 52 citations in OpenAlex.
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- The cerebellar deep nuclei: a patch for rate codes?Frontiers in neural circuits · 2025Article
- The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells.Frontiers in physiology · 2025Review
- Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Efficient information coding and degeneracy in the nervous system.Current opinion in neurobiology · 2022Review
- Altered Synaptic Transmission and Excitability of Cerebellar Nuclear Neurons in a Mouse Model of Duchenne Muscular Dystrophy.Frontiers in cellular neuroscience · 2022Article
- Significance of GABAInternational journal of molecular sciences · 2021Review
- Differential regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses.EMBO reports · 2021Article
- Temporal dynamics of learning-promoted synaptic diversity in CA1 pyramidal neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Mechanisms of GABAScientific reports · 2019Article
- Learning Promotes Subfield-Specific Synaptic Diversity in Hippocampal CA1 Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell - DCN Synapse.Frontiers in synaptic neuroscience · 2019Article
- Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Universal Biomolecular Concentrator To Enhance Biomolecular Surface Binding Based on Acoustic NEMS Resonator.ACS central science · 2018Article
- Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex.Cell reports · 2016Article
- Maturation of membrane properties of neurons in the rat deep cerebellar nuclei.Developmental neurobiology · 2014Article
- Differential GABAergic and glycinergic inputs of inhibitory interneurons and Purkinje cells to principal cells of the cerebellar nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.Frontiers in cellular neuroscience · 2014Article
- Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance.Cerebellum (London, England) · 2013Article
- Noradrenergic control of neuronal firing in cerebellar nuclei: modulation of GABA responses.Cerebellum (London, England) · 2013Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neurons of the cerebellar nuclei receive GABAergic input from Purkinje cells. Purkinje boutons have several closely spaced presynaptic densities without GABA transporters, raising the possibility that neurotransmitter released by one presynaptic site diffuses to multiple postsynaptic sites. To test whether such local spillover may contribute to transmission, we studied gating of GABA(A) receptors at 31-33 degrees C in cerebellar nuclear neurons acutely dissociated from mice. Currents were evoked by rapid application of long steps, brief pulses, and high-frequency trains of GABA to outside-out patches. Receptors desensitized and deactivated rapidly, and dose-response measurements estimated an EC(50) of approximately 30 microM. From these data, a kinetic scheme was developed that replicated the recorded currents. Next, we simulated diffusion of GABA in the synaptic cleft, constrained by previous electron microscopic data, and drove the kinetic GABA(A) receptor model with modeled concentration transients. Simulations predicted receptor occupancies of approximately 100% directly opposite the release site and approximately 50% at distant postsynaptic densities, such that receptors up to 700 nm from a release site opened on the timescale of the inhibitory postsynaptic currents before desensitizing. Further simulations of probabilistic release from multiple-site boutons suggested that local spillover-mediated transmission slows the onset and limits the extent of depression during high-frequency signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.