ArticleEnvironmental health perspectives2005
Assessment of autoimmune responses associated with asbestos exposure in Libby, Montana, USA.
Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.Particle and fibre toxicology · 2022Pooled it
- Nested case-control study of autoimmune disease in an asbestos-exposed population.Environmental health perspectives · 2006Trial
- Effects of different amosite preparations on macrophages, lung damages, and autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2024Article
- Pneumoconiosis combined with connective tissue disease in China: a cross-sectional study.BMJ open · 2023Article
- B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles.Frontiers in toxicology · 2023Review
- Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan.International journal of molecular sciences · 2021Article
- Association of antinuclear antibody seropositivity with inhaled environmental exposures in patients with interstitial lung disease.ERJ open research · 2021Article
- Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia.Journal of toxicology and environmental health. Part A · 2021Article
- Asbestos in High-Risk Communities: Public Health Implications.International journal of environmental research and public health · 2021Review
- Mechanisms of Environment-Induced Autoimmunity.Annual review of pharmacology and toxicology · 2021Article
- Asbestos exposure and autoantibody titers.Annals of occupational and environmental medicine · 2020Article
- Follow-Up of the Libby, Montana Screening Cohort: A 17-Year Mortality Study.Journal of occupational and environmental medicine · 2020Article
- Oxidative potential (OP) and mineralogy of iron ore particulate matter at the Gol-E-Gohar Mining and Industrial Facility (Iran).Environmental geochemistry and health · 2018Article
- Analysis of autoantibody profiles in two asbestiform fiber exposure cohorts.Journal of toxicology and environmental health. Part A · 2018Article
- Antinuclear antibodies in healthy people and non-rheumatic diseases - diagnostic and clinical implications.Reumatologia · 2018Review
- Mesothelial cell autoantibodies upregulate transcription factors associated with fibrosis.Inhalation toxicology · 2017Article
- Principal components analysis to identify influences on research communication and engagement during an environmental disaster.BMJ open · 2016Article
- Libby amphibole-induced mesothelial cell autoantibodies bind to surface plasminogen and alter collagen matrix remodeling.Physiological reports · 2016Article
- Libby amphibole-induced mesothelial cell autoantibodies promote collagen deposition in mice.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004.Environmental health perspectives · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Systemic autoimmune responses are associated with certain environmental exposures, including crystalline particles such as silica. Positive antinuclear antibody (ANA) tests have been reported in small cohorts exposed to asbestos, but many questions remain regarding the prevalence, pattern, and significance of autoantibodies associated with asbestos exposures. The population in Libby, Montana, provides a unique opportunity for such a study because of both occupational and environmental exposures that have occurred as a result of the mining of asbestos-contaminated vermiculite near the community. As part of a multifaceted assessment of the impact of asbestos exposures on this population, this study explored the possibility of exacerbated autoimmune responses. Age- and sex-matched sets of 50 serum samples from Libby and Missoula, Montana (unexposed), were tested for ANA on HEp-2 cells using indirect immunofluorescence. Data included frequency of positive tests, ANA titers, staining patterns, and scored fluorescence intensity, all against known controls. Serum immunoglobulin A (IgA), rheumatoid factor, and antibodies to extractable nuclear antigen (ENA) were also tested. The Libby samples showed significantly higher frequency of positive ANA and ENA tests, increased mean fluorescence intensity and titers of the ANAs, and higher serum IgA, compared with Missoula samples. In the Libby samples, positive correlations were found between ANA titers and both lung disease severity and extent of exposure. The results support the hypothesis that asbestos exposure is associated with autoimmune responses and suggests that a relationship exists between those responses and asbestos-related disease processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.