ArticleGenomics, proteomics & bioinformatics2003
The structure analysis and antigenicity study of the N protein of SARS-CoV.
Article in Genomics, proteomics & bioinformatics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Colorimetric and Raman dual-mode lateral flow immunoassay detection of SARS-CoV-2 N protein antibody based on Ag nanoparticles with ultrathin Au shell assembled onto FeAnalytical and bioanalytical chemistry · 2023Article
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- ELISA-Based Analysis Reveals an Anti-SARS-CoV-2 Protein Immune Response Profile Associated with Disease Severity.Journal of clinical medicine · 2022Article
- Mass Spectrometry Analysis of SARS-CoV-2 Nucleocapsid Protein Reveals Camouflaging Glycans and Unique Post-Translational Modifications.Infectious microbes & diseases · 2021Article
- COVID-19: Myths and Reality.Biochemistry. Biokhimiia · 2021Review
- Observational
- Article
- Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain:Journal of immunology research · 2020Article
- SARS coronavirus: unusual lability of the nucleocapsid protein.Biochemical and biophysical research communications · 2008Article
- The nucleocapsid protein of SARS-associated coronavirus inhibits B23 phosphorylation.Biochemical and biophysical research communications · 2008Article
- Sensitive and specific enzyme-linked immunosorbent assay using chemiluminescence for detection of severe acute respiratory syndrome viral infection.Journal of clinical microbiology · 2008Article
- Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB.Virology · 2007Article
- Antigenic and cellular localisation analysis of the severe acute respiratory syndrome coronavirus nucleocapsid protein using monoclonal antibodies.Virus research · 2006Article
- Retracted: Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein.The international journal of biochemistry & cell biology · 2006Article
- Antigenicity analysis of different regions of the severe acute respiratory syndrome coronavirus nucleocapsid protein.Clinical chemistry · 2004Article
- Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).Genomics, proteomics & bioinformatics · 2003Review
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Coronaviridae family is characterized by a nucleocapsid that is composed of the genome RNA molecule in combination with the nucleoprotein (N protein) within a virion. The most striking physiochemical feature of the N protein of SARS-CoV is that it is a typical basic protein with a high predicted pI and high hydrophilicity, which is consistent with its function of binding to the ribophosphate backbone of the RNA molecule. The predicted high extent of phosphorylation of the N protein on multiple candidate phosphorylation sites demonstrates that it would be related to important functions, such as RNA-binding and localization to the nucleolus of host cells. Subsequent study shows that there is an SR-rich region in the N protein and this region might be involved in the protein-protein interaction. The abundant antigenic sites predicted in the N protein, as well as experimental evidence with synthesized polypeptides, indicate that the N protein is one of the major antigens of the SARS-CoV. Compared with other viral structural proteins, the low variation rate of the N protein with regards to its size suggests its importance to the survival of the virus.
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