ArticleThe Journal of general physiology2005
Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels.
Article in The Journal of general physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Fifty years of gating currents and channel gating.The Journal of general physiology · 2023Review
- S4-S5 linker movement during activation and inactivation in voltage-gated KProceedings of the National Academy of Sciences of the United States of America · 2018Article
- The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility.The Journal of physiology · 2015Review
- Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.The Journal of biological chemistry · 2013Article
- Molecular mechanism for depolarization-induced modulation of Kv channel closure.The Journal of general physiology · 2012Article
- Being flexible: the voltage-controllable activation gate of kv channels.Frontiers in pharmacology · 2012Article
- Coupling of voltage-sensors to the channel pore: a comparative view.Frontiers in pharmacology · 2012Article
- Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating.Biophysical journal · 2010Article
- Coupling of S4 helix translocation and S6 gating analyzed by molecular-dynamics simulations of mutated Kv channels.Biophysical journal · 2009Article
- Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.The Journal of general physiology · 2008Article
- Direct analysis of cooperativity in multisubunit allosteric proteins.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Voltage-gated K(+) channels play a central role in the modulation of excitability. In these channels, the voltage-dependent movement of the voltage sensor (primarily S4) is coupled to the (S6) gate that opens the permeation pathway. Because of the tetrameric structure, such coupling could occur within each subunit or between adjacent subunits. To discriminate between these possibilities, we analyzed various combinations of a S4 mutation (R401N) and a S6 mutation (P511G) in hKv1.5, incorporated into tandem constructs to constrain subunit stoichiometry. R401N shifted the voltage dependence of activation to negative potentials while P511G did the opposite. When both mutations were introduced in the same alpha-subunit of the tandem, the positive shift of P511G was compensated by the negative shift of R401N. With each mutation in a separate subunit of a tandem, this compensation did not occur. This suggests that for Kv channels, the coupling between voltage sensing and gating reflects primarily an intrasubunit interaction.
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