ArticleThe Journal of experimental medicine2005
Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
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- Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies?Inflammatory bowel diseases · 2023Review
- SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation.Gastroenterology · 2022Article
- Alternative pathways for the development of lymphoid structures in humans.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Appendix in Parkinson's Disease: From Vestigial Remnant to Vital Organ?Journal of Parkinson's disease · 2019Review
- The wide utility of rabbits as models of human diseases.Experimental & molecular medicine · 2018Review
- Review
- Insulin resistance is associated with specific gut microbiota in appendix samples from morbidly obese patients.American journal of translational research · 2016Article
- Primary immunoglobulin repertoire development: time and space matter.Current opinion in immunology · 2015Review
- Chemokine-mediated B cell trafficking during early rabbit GALT development.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Culture-independent evaluation of the appendix and rectum microbiomes in children with and without appendicitis.PloS one · 2014Article
- Systematic characterization and comparative analysis of the rabbit immunoglobulin repertoire.PloS one · 2014Article
- Article
- In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Mechanism for pre-B cell loss in VH-mutant rabbits.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Analyses of recombinant stereotypic IGHV3-21-encoded antibodies expressed in chronic lymphocytic leukemia.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- B cell development in GALT: role of bacterial superantigen-like molecules.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Characterization of rabbit CD5 isoforms.Molecular immunology · 2009Article
- Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants.The Journal of experimental medicine · 2008Article
- Microbial induction of B and T cell areas in rabbit appendix.Developmental and comparative immunology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Gut-associated lymphoid tissues (GALTs) interact with intestinal microflora to drive GALT development and diversify the primary antibody repertoire; however, the molecular mechanisms that link these events remain elusive. Alicia rabbits provide an excellent model to investigate the relationship between GALT, intestinal microflora, and modulation of the antibody repertoire. Most B cells in neonatal Alicia rabbits express V(H)n allotype immunoglobulin (Ig)M. Within weeks, the number of V(H)n B cells decreases, whereas V(H)a allotype B cells increase in number and become predominant. We hypothesized that the repertoire shift from V(H)n to V(H)a B cells results from interactions between GALT and intestinal microflora. To test this hypothesis, we surgically removed organized GALT from newborn Alicia pups and ligated the appendix to sequester it from intestinal microflora. Flow cytometry and nucleotide sequence analyses revealed that the V(H)n to V(H)a repertoire shift did not occur, demonstrating the requirement for interactions between GALT and intestinal microflora in the selective expansion of V(H)a B cells. By comparing amino acid sequences of V(H)n and V(H)a Ig, we identified a putative V(H) ligand binding site for a bacterial or endogenous B cell superantigen. We propose that interaction of such a superantigen with V(H)a B cells results in their selective expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.