ArticleProceedings of the National Academy of Sciences of the United States of America2005
Zebrafish GADD45beta genes are involved in somite segmentation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Gadd45 in Neuronal Development, Function, and Injury.Advances in experimental medicine and biology · 2022Review
- Roles for GADD45 in Development and Cancer.Advances in experimental medicine and biology · 2022Review
- Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.Science advances · 2020Article
- Sea lampreys elicit strong transcriptomic responses in the lake trout liver during parasitism.BMC genomics · 2016Article
- GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway.Cell death & disease · 2016Article
- TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish.RNA biology · 2014Article
- Vap (Vascular Associated Protein): a novel factor involved in erythropoiesis and angiogenesis.Biochemical and biophysical research communications · 2012Article
- Gadd45 proteins: relevance to aging, longevity and age-related pathologies.Ageing research reviews · 2012Review
- Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- The BEM46-like protein appears to be essential for hyphal development upon ascospore germination in Neurospora crassa and is targeted to the endoplasmic reticulum.Current genetics · 2009Article
- Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo.PloS one · 2008Article
- Article
- Setting the tempo in development: an investigation of the zebrafish somite clock mechanism.PLoS biology · 2007Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Somites in vertebrates are periodic segmented structures that give rise to the vertebrae and muscles of body. Somites are generated from presomitic mesoderm (PSM), but it is not fully understood how cellular differentiation and segment formation are achieved in the anterior PSM. We report here that zebrafish gadd45beta1 and gadd45beta2 genes are periodically expressed as paired stripes adjacent to the neural tube in the anterior PSM region where presomitic cells mature. In mammals, it is known that GADD45 (growth arrest and DNA damage) family proteins play a role in cell-cycle control. We found that both knockdown and overexpression of gadd45beta genes caused somite defects with different consequences for marker gene expression. Knockdown of gadd45beta genes with antisense morpholino oligonucleotides caused a broad expansion of mesp-a in the PSM, and both cyclic expression of her1 and segmented expression of MyoD were disorganized. On the other hand, injection of gadd45beta1 or gadd45beta2 suppressed expression of mesp-a and her1 in anterior PSM and MyoD in paraxial mesoderm. These results indicate that regulated expression of gadd45beta genes in the anterior PSM is required for somite segmentation.
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