ArticleJournal of clinical pathology2005
Intraductal papillary mucinous neoplasm of the pancreas in a patient with attenuated familial adenomatous polyposis.
Article in Journal of clinical pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum: A case series and systematic literature review.World journal of gastroenterology · 2022Pooled it
- Precursor lesions in familial and hereditary pancreatic cancer.Familial cancer · 2024Review
- Synchronous manifestation of colorectal cancer and intraductal papillary mucinous neoplasms.World journal of clinical cases · 2023Review
- Intraductal Papillary Mucinous Neoplasms in Hereditary Cancer Syndromes.Biomedicines · 2022Review
- Solid-pseudopapillary neoplasm of the pancreas in a patient with familial adenomatous polyposis: a case report.Surgical case reports · 2021Article
- Effect of Adenomatous Polyposis Coli Loss on Tumorigenic Potential in Pancreatic Ductal Adenocarcinoma.Cells · 2019Article
- Early Detection of Pancreatic Cancer: Opportunities and Challenges.Gastroenterology · 2019Review
- Characteristics and Clinical Outcomes of Individuals at High Risk for Pancreatic Cancer: A Descriptive Analysis from a Comprehensive Cancer Center.Gastrointestinal disorders (Basel, Switzerland) · 2019Article
- Double germline mutations in APC and BRCA2 in an individual with a pancreatic tumor.Familial cancer · 2017Article
- Cyst Features and Risk of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas: Imaging and Pathology.Viszeralmedizin · 2015Review
- Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.World journal of gastroenterology · 2013Review
- Intraductal papillary mucinous neoplasms of the pancreas--a surgical disease.Nature reviews. Gastroenterology & hepatology · 2012Review
- Intraductal papillary mucinous neoplasm of the pancreas: an update.Scientifica · 2012Review
- Management of mucin-producing cystic neoplasms of the pancreas.The oncologist · 2009Review
- Intraductal papillary mucinous neoplasm of the pancreas with loss of mismatch repair in a patient with Lynch syndrome.The American journal of surgical pathology · 2009Article
- Extra-intestinal manifestations of familial adenomatous polyposis.Annals of surgical oncology · 2008Review
- Occurrence of adenomas in the pouch and small intestine of FAP patients after proctocolectomy with ileoanal pouch construction.International journal of colorectal disease · 2008Article
- APC gene mutations causing familial adenomatous polyposis in Polish patients.Journal of applied genetics · 2008Article
- Article
- Malignancies associated with intraductal papillary mucinous neoplasm of the pancreas.World journal of gastroenterology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 67 year old man with a clinical diagnosis of attenuated familial adenomatous polyposis (AFAP) and a past history of synchronous colon cancers in the transverse colon was also found to have an intraductal papillary mucinous neoplasm (IPMN) of the pancreas. In addition, several foci of heterotopic gastric oxyntic mucosa were noted in the duodenum, interspersed with flat and polypoid adenomas. The duodenal adenomas showed low grade dysplasia, loss of adenomatous polyposis coli (APC) protein expression, but retention of beta catenin staining, localised to the nucleus and cytoplasm. The IPMN in the pancreas showed an identical immunohistochemical profile to the duodenal adenomas. The heterotopic gastric foci in the duodenum were negative for the APC protein, and beta catenin staining was membranous in location. Although the patient did not show germline truncating APC mutations or mutations in the MYH gene, the past history, clinical features, and immunohistochemical profile of the various lesions suggest strongly that the IPMN is part of the spectrum of lesions encountered in AFAP. Whether the heterotopic oxyntic gastric mucosa in the duodenum is also related is unclear, but it may represent a forme fruste of fundic gland polyps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.