ArticleJournal of clinical pathology2005
Association of specific genotype and haplotype of p53 gene with cervical cancer in India.
Article in Journal of clinical pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Association between theFrontiers in oncology · 2025Pooled it
- Meta-Analysis of Polymorphic Variants Conferring Genetic Risk to Cervical Cancer in Indian Women Supports CYP1A1 as an Important Associated LocusAsian Pacific journal of cancer prevention : APJCP · 2018Pooled it
- Linkage disequilibrium and haplotypes of fiveJournal of genetics · 2020Article
- SALL4 promotes the tumorigenicity of cervical cancer cells through activation of the Wnt/β-catenin pathway via CTNNB1.Cancer science · 2019Article
- Effect of p53 codon 72 polymorphism on the survival outcome in advanced stage cervical cancer patients in India.The Indian journal of medical research · 2016Article
- Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Article
- Article
- The preliminary study of p53 codon 72 polymorphism and risk of cervical carcinoma in Gabonese women.Medical oncology (Northwood, London, England) · 2015Article
- Association of TP53 codon 72 and intron 3 16-bp Ins/Del polymorphisms with cervical cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- The determination of genetic markers of age-related cancer pathologies in populations from Kazakhstan.Frontiers in genetics · 2013Article
- Role of p53 and p73 genes polymorphisms in susceptibility to esophageal cancer: a case control study in a northern Indian population.Molecular biology reports · 2012Article
- A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer.Indian journal of human genetics · 2011Article
- p53 codon 72 polymorphism and risk of cervical carcinoma in Moroccan women.Medical oncology (Northwood, London, England) · 2010Article
- Polymorphisms in p53 and the p53 pathway: roles in cancer susceptibility and response to treatment.Journal of cellular and molecular medicine · 2009Review
- Detection of antibodies against epidermodysplasia verruciformis-associated canine papillomavirus 3 in sera of dogs from Europe and Africa by enzyme-linked immunosorbent assay.Clinical and vaccine immunology : CVI · 2009Article
- Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population.American journal of medical genetics. Part A · 2008Article
- Interplay between human papilloma virus infection and p53 gene alterations in head and neck squamous cell carcinoma of an Indian patient population.Journal of clinical pathology · 2007Article
- Gene discovery in cervical cancer : towards diagnostic and therapeutic biomarkers.Molecular diagnosis & therapy · 2007Review
- Polymorphisms in the p53 pathway.Oncogene · 2006Review
- Genetic and epigenetic biomarkers in cancer : improving diagnosis, risk assessment, and disease stratification.Molecular diagnosis & therapy · 2006Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe predictive value of codon 72 arginine homozygosity at the p53 gene for human papilloma virus associated cervical cancer risk remains inconclusive. It has also been proposed that the inheritance of specific germline haplotypes based on three biallelic polymorphisms of p53 (intron 3 16 bp duplication, codon 72 Bst UI (Arg/Pro), and intron 6 Nci I restriction fragment length polymorphism at nucleotide 13494) is a better predictor of various cancer risks.
aimsTo determine the genotype and haplotype frequency of these three p53 polymorphisms in 61 patients with cervical squamous cell carcinoma and 94 ethnically matched controls from the eastern region of India and estimate the risk, if any, of specific genotypes and haplotypes.
methodsSamples were genotyped by polymerase chain reaction followed by variant specific restriction enzyme digestion. Haplotypes were estimated by the maximum likelihood method using the expectation maximisation algorithm.
resultsGenotype distributions of the three polymorphisms in patients and controls showed a good fit to the Hardy-Weinberg equilibrium. The p53 codon 72 arginine homozygous genotype was significantly over represented in patients compared with controls. Those with the homozygous arginine genotype exhibited a 2.59 fold higher risk of developing squamous cell carcinoma of the uterine cervix. A significant risk was also seen with a combination of two haplotypes, 1-2-1 and 1-2-2.
conclusionp53 codon 72 arginine homozygotes appear to be at greater risk of developing squamous cell carcinoma of the uterine cervix. The high risk haplotypes 1-2-1 and 1-2-2 also contain the arginine allele, further strengthening this conclusion.
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