ArticleThe American journal of pathology1992
Application of a multiprobe RNase protection assay and junctional sequences to define V beta gene diversity in Sezary syndrome.
Article in The American journal of pathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 36 citations in OpenAlex.
- Cytokine multiplex analysis.Methods in molecular biology (Clifton, N.J.) · 2009Article
- T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitis.The Journal of clinical investigation · 1996Article
- Cutaneous lymphoproliferative disorders: strategies for molecular biological analysis and their major findings.Springer seminars in immunopathology · 1992Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Nineteen patients with mycosis fungoides/Sezary syndrome (MF/SZ), a malignancy of the mature helper T-cell phenotype (CD4+TCR alpha beta+), were screened for clonotypic V beta expansions in peripheral blood with a multiprobe RNase protection assay. A different predominant V beta gene was identified in 9 of 14 patients with high peripheral blood CD4/CD8 ratios, whereas 4 of these patients showed T-cell expansions expressing V beta genes other than those included in the assay. In contrast, five patients with few, if any, malignant cells in the circulation had V beta expression levels similar to that in normal peripheral blood. A unique V-D-J sequence was found for each highly expressed V beta gene, thereby documenting monoclonality of the expanded T-cell populations. Polymerase chain reaction (PCR) primers specific for the D-J beta junction accurately identified the corresponding malignant clonotype in peripheral blood. The diverse TCR V beta gene usage found in these MF/SZ patients suggests that T-cell receptor (TCR) specificity has no bearing on this disease.
Indexed as
Identifiers
1562047PMC1886373W2112655147What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.