ArticleBMC bioinformatics2004
A database for G proteins and their interaction with GPCRs.
Article in BMC bioinformatics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Association of G-protein β3 subunit C825T polymorphism with essential hypertension: evidence from 63 729 subjects.Journal of human hypertension · 2017Pooled it
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- GNB3 c.825C>T (rs5443) Polymorphism and Risk of Acute Cardiovascular Events after Renal Allograft TransplantInternational journal of molecular sciences · 2022Article
- Development and validation of whole genome-wide and genic microsatellite markers in oil palm (Elaeis guineensis Jacq.): First microsatellite database (OpSatdb).Scientific reports · 2019Article
- Cardiovascular diseases-relatedJournal of inflammation (London, England) · 2016Article
- Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells.PloS one · 2010Article
- GPCRs, G-proteins, effectors and their interactions: human-gpDB, a database employing visualization tools and data integration techniques.Database : the journal of biological databases and curation · 2010Article
- Early effects of FOLFOX treatment of colorectal tumour in an animal model: assessment of changes in gene expression and FDG kinetics.European journal of nuclear medicine and molecular imaging · 2009Article
- Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region.The Journal of biological chemistry · 2008Article
- Whole proteome identification of plant candidate G-protein coupled receptors in Arabidopsis, rice, and poplar: computational prediction and in-vivo protein coupling.Genome biology · 2008Article
- Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets.Current medicinal chemistry · 2008Review
- Taste and pheromone perception in the fruit fly Drosophila melanogaster.Pflugers Archiv : European journal of physiology · 2007Review
- RINGdb: an integrated database for G protein-coupled receptors and regulators of G protein signaling.BMC genomics · 2006Article
- Prediction of GPCR-G protein coupling specificity using features of sequences and biological functions.Genomics, proteomics & bioinformatics · 2006Article
- Predicting the coupling specificity of GPCRs to G-proteins by support vector machines.Genomics, proteomics & bioinformatics · 2005Article
- A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models.BMC bioinformatics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundG protein-coupled receptors (GPCRs) transduce signals from extracellular space into the cell, through their interaction with G proteins, which act as switches forming hetero-trimers composed of different subunits (alpha,beta,gamma). The alpha subunit of the G protein is responsible for the recognition of a given GPCR. Whereas specialised resources for GPCRs, and other groups of receptors, are already available, currently, there is no publicly available database focusing on G Proteins and containing information about their coupling specificity with their respective receptors. DESCRIPTION: gpDB is a publicly accessible G proteins/GPCRs relational database. Including species homologs, the database contains detailed information for 418 G protein monomers (272 Galpha, 87 Gbeta and 59 Ggamma) and 2782 GPCRs sequences belonging to families with known coupling to G proteins. The GPCRs and the G proteins are classified according to a hierarchy of different classes, families and sub-families, based on extensive literature searchs. The main innovation besides the classification of both G proteins and GPCRs is the relational model of the database, describing the known coupling specificity of the GPCRs to their respective alpha subunit of G proteins, a unique feature not available in any other database. There is full sequence information with cross-references to publicly available databases, references to the literature concerning the coupling specificity and the dimerization of GPCRs and the user may submit advanced queries for text search. Furthermore, we provide a pattern search tool, an interface for running BLAST against the database and interconnectivity with PRED-TMR, PRED-GPCR and TMRPres2D.
conclusionsThe database will be very useful, for both experimentalists and bioinformaticians, for the study of G protein/GPCR interactions and for future development of predictive algorithms. It is available for academics, via a web browser at the URL: http://bioinformatics.biol.uoa.gr/gpDB.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.