ArticleProteomics2005
Differential protein expression by Porphyromonas gingivalis in response to secreted epithelial cell components.
Article in Proteomics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Effect of rubusoside, a natural sucrose substitute, on the metabolism of Scardovia wiggsiae: a novel potential cariogenic pathogen.BMC biology · 2025Article
- cAMP-independent Crp homolog adds to the multi-layer regulatory network inFrontiers in cellular and infection microbiology · 2025Article
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells.GeroScience · 2024Article
- Genes Contributing toFrontiers in cellular and infection microbiology · 2017Article
- Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts.Scientific reports · 2016Article
- Investigation of the Cell Surface Proteome of Human Periodontal Ligament Stem Cells.Stem cells international · 2016Article
- Invasion of Porphyromonas gingivalis strains into vascular cells and tissue.Journal of oral microbiology · 2015Article
- Microbiology and treatment of acute apical abscesses.Clinical microbiology reviews · 2013Review
- Insights into the virulence of oral biofilms: discoveries from proteomics.Expert review of proteomics · 2012Review
- Article
- Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats.Infection and immunity · 2010Article
- Translocation of Porphyromonas gingivalis gingipain adhesin peptide A44 to host mitochondria prevents apoptosis.Infection and immunity · 2010Article
- Tetratricopeptide repeat protein-associated proteins contribute to the virulence of Porphyromonas gingivalis.Infection and immunity · 2010Article
- Bacterial invasion of epithelial cells and spreading in periodontal tissue.Periodontology 2000 · 2010Review
- Cellular and bacterial profiles associated with oral epithelium-microbiota interactions.Periodontology 2000 · 2010Review
- Porphyromonas gingivalis ferrous iron transporter FeoB1 influences sensitivity to oxidative stress.Infection and immunity · 2010Article
- Porphyromonas gingivalis strain diversity.Journal of clinical microbiology · 2009Article
- Response of Porphyromonas gingivalis to heme limitation in continuous culture.Journal of bacteriology · 2009Article
- The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay.Microbiology (Reading, England) · 2008Review
- Role of Porphyromonas gingivalis SerB in gingival epithelial cell cytoskeletal remodeling and cytokine production.Infection and immunity · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The human oral pathogen Porphyromonas gingivalis colonizes the gingival crevice and invades gingival epithelial cells. Multidimensional capillary high-performance liquid chromatography coupled with tandem mass spectrometry and two-dimensional gel electrophoresis were used to analyze the proteome of P. gingivalis as it adapts to a set of experimental conditions designed to reflect important features of an epithelial cell environment. 1014 proteins (46% of the total theoretical proteome) were identified in four independent analyses; 479 of these proteins showed evidence of differential expression after exposure of P. gingivalis to either conditioned epithelial cell growth medium or control conditions: i.e., they were only detected under one set of conditions. Moreover, 276 genes annotated as hypothetical were found to encode expressed proteins. Among the proteins up-regulated in the presence of epithelial cell components were a homolog of the internalin proteins of Listeria monocytogenes and subunits of the ATP-dependent Clp protease complex. Insertional inactivation of clpP, encoding the Clp proteolytic subunit, resulted in approximately a 50% reduction in invasion of P. gingivalis. These results suggest that adaptation to an epithelial cell environment induces a major shift in the expressed proteome of the organism. Furthermore, ClpP, that is up-regulated in this environment, is required for optimal invasive activity of P. gingivalis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.