ArticleCellular and molecular life sciences : CMLS2005
Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix.
Article in Cellular and molecular life sciences : CMLS, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- CXCR4/CXCL12 blockade therapy; a new horizon in TNBC therapy.Medical oncology (Northwood, London, England) · 2025Review
- The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis.International journal of molecular sciences · 2020Review
- Identification and functional characterization of TRPA1 in human myoblasts.Pflugers Archiv : European journal of physiology · 2016Article
- ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.The Journal of clinical investigation · 2014Article
- BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin Va via Erk signaling.Oxidative medicine and cellular longevity · 2014Article
- PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change.Immunopharmacology and immunotoxicology · 2013Article
- The Role of chemokine receptor CXCR4 in breast cancer metastasis.American journal of cancer research · 2013Article
- Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism.BMC cancer · 2011Article
- Cytoskeletal cross-linking and bundling in motor-independent contraction.Current biology : CB · 2010Review
- PC-3 prostate carcinoma cells release signal substances that influence the migratory activity of cells in the tumor's microenvironment.Cell communication and signaling : CCS · 2010Article
- ERK activation and cell growth require CaM kinases in MCF-7 breast cancer cells.Molecular and cellular biochemistry · 2010Article
- Divergent effects of norepinephrine, dopamine and substance P on the activation, differentiation and effector functions of human cytotoxic T lymphocytes.BMC immunology · 2009Article
- Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion.The American journal of pathology · 2009Article
- Localization of myosin and actin in the pelage and whisker hair follicles of rat.Acta histochemica et cytochemica · 2006Article
- Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The migration of cells is a complex regulatory process which results in the generation of motor forces through the reorganization of the cytoskeleton. Here we present a comparative study of the expression and involvement of myosin in the regulation of the physiological migration of leukocytes and the pathological migration of tumor cells. We show that the involvement of myosin in the migration is distinct in these two cell types. In leukocytes, the activity of non-muscle myosin II is essential for both the spontaneous (matrix-induced) migration and the migration induced by ligands to G protein-coupled receptors, i.e. chemokines and neurotransmitters. In contrast, spontaneous tumor cell migration is largely independent of non-muscle myosin II activity, whereas the norepinephrine-induced migration is completely inhibited by either direct inhibition of non-muscle myosin II or of the kinases phosphorylating the myosin light chain, namely ROCK or the calcium/calmodulin-dependent myosin light-chain kinase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.