ArticleThorax2005
Peak oxygen uptake and mortality in children with cystic fibrosis.
Article in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe Cystic Fibrosis Lung Disease
Development; Feasibility/Safety and Validation of the Alfred Step Test Exercise Protocol (A-STEP) Developed for Adults With Cystic Fibrosis:
Who cites it
55 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Impact of Exercise Intervention on Pulmonary and Physical Function in Patients With Cystic Fibrosis:Saudi medical journal · 2026Pooled it
- Physical activity and exercise training in cystic fibrosis.The Cochrane database of systematic reviews · 2022Pooled it
- Exercise versus airway clearance techniques for people with cystic fibrosis.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF).American journal of respiratory and critical care medicine · 2022Trial
- Trainability of Health-Related and Motor Performance Fitness in Adults with Cystic Fibrosis within a 12-Month Partially Supervised Exercise Program.Pulmonary medicine · 2021Trial
- Exercise capacity and muscle fatiguability alterations following a progressive maximal exercise of lower extremities in children with cystic fibrosis.African health sciences · 2018Trial
- Sildenafil improves vascular endothelial function in patients with cystic fibrosis.American journal of physiology. Heart and circulatory physiology · 2018Trial
- The Coupling of Peripheral Blood Pressure and Ventilatory Responses during Exercise in Young Adults with Cystic Fibrosis.PloS one · 2016Trial
- Moderate intensity exercise mediates comparable increases in exhaled chloride as albuterol in individuals with cystic fibrosis.Respiratory medicine · 2015Trial
- Impact of exacerbations of cystic fibrosis on muscle strength.Respiratory research · 2013Trial
- Interrelationships among handgrip strength, body composition, physical activity, and quality of life in adults with cystic fibrosis: A cross-sectional study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Observational
- Inflammation and oxidative stress in the sputum of patients with cystic fibrosis: correlations with lung function, aerobic fitness, and morbidity.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Observational
- Strength-Oriented Virtual Exercise Training Intervention in Children and Adolescents with Cystic Fibrosis Under CFTR Modulators (the FIQMODE Study): Study Protocol for a Randomized Controlled Trial.Current protocols · 2025Article
- Physical Training and Pulmonary Rehabilitation in Patients with Cystic Fibrosis: A Systematic Review and Meta-Analysis of Clinical Trials.Healthcare (Basel, Switzerland) · 2025Review
- Long-term exercise capacity in paediatric cystic fibrosis: a modern era perspective.ERJ open research · 2025Article
- Impact of CFTR modulators on exercise capacity in adolescents with cystic fibrosis.ERJ open research · 2024Article
- Guidance and standard operating procedures for functional exercise testing in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Skeletal muscle contributions to reduced fitness in cystic fibrosis youth.Frontiers in pediatrics · 2023Article
- Exercise as an Airway Clearance Technique in people with Cystic Fibrosis (ExACT-CF): rationale and study protocol for a randomised pilot trial.NIHR open research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSingle measurements of peak oxygen uptake (VO2) have been shown to predict mortality in patients with cystic fibrosis (CF) although no longitudinal study of serial measurements has been reported in children. A study was undertaken to determine whether the initial, final, or the rate of fall of forced expiratory volume in 1 second (FEV1) or peak VO2 was a better predictor of mortality.
methodsTwenty eight children aged 8-17 years with CF performed annual pulmonary function and maximal exercise tests over a 5 year period to determine FEV1 and peak VO2, magnitude of their change over time, and survival over the subsequent 7-8 years. Analysis was done using Kaplan-Meier curves and Cox proportional hazard model.
resultsPeak VO2 fell during the observation period in 70% of the patients, with a mean annual decline of 2.1 ml/min/kg. Initial peak VO2 was not predictive of mortality but rate of decline and final peak VO2 of the series were significant predictors. Patients with peak VO2 less than 32 ml/min/kg exhibited a dramatic increase in mortality, in contrast to those whose peak VO2 exceeded 45 ml/min/kg, none of whom died. The first, last, and rate of decline in FEV1 over time were all significant predictors of mortality.
conclusionsHigher peak VO2 is a marker for longer survival in CF patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.