ArticleThorax2005
Diagnostic accuracy of bronchodilator responsiveness in wheezy children.
Article in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01500525 (A Prospective Observational Study in a Tertiary Pediatric Hospital in Beijing to Understand the Accuracy of Bronchodilator Response), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Observational Study in a Tertiary Pediatric Hospital in Beijing to Understand the Accuracy of Bronchodilator Response (BDR) in Chinese Controller Naive Asthmatic Children Between the Age of 4~12 Years Old
Who cites it
24 citing papers in PubMed, 91 citations in OpenAlex.
- Diagnostic accuracy of the bronchodilator response in children.The Journal of allergy and clinical immunology · 2013Trial
- Oscillometric and spirometric bronchodilator response in preschool children with and without asthma.Canadian respiratory journalTrial
- Real-world feasibility of adapted European Respiratory Society asthma diagnosis guidelines for school-aged children.ERJ open research · 2026Article
- Impact of varying childhood asthma definitions on incidence and clinical outcomes.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Assessment of Bronchodilator Responsiveness and Spirometric Patterns in Patients with Rhinitis and Suspected Asthma.Journal of asthma and allergy · 2026Article
- Race-Neutral Equations and Pulmonary Function Test Interpretation in Two Pediatric Cohorts.The Journal of pediatrics · 2024Article
- Association between severe bronchiolitis in infancy and age 6-year lung function.Respiratory medicine · 2023Article
- Effect of radon exposure on asthma morbidity in the School Inner-City Asthma study.Pediatric pulmonology · 2023Article
- Routine FEVBreathe (Sheffield, England) · 2023Review
- Combined forced oscillation and fractional-order modeling in patients with work-related asthma: a case-control study analyzing respiratory biomechanics and diagnostic accuracy.Biomedical engineering online · 2020Article
- Reduced expiratory variability index (EVI) is associated with controller medication withdrawal and symptoms in wheezy children aged 1-5 years.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Article
- A clinical study to determine the threshold of bronchodilator response for diagnosing asthma in Chinese children.World journal of pediatrics : WJP · 2019Article
- Long-term pulmonary complications in perinatally HIV-infected youth.The Journal of allergy and clinical immunology · 2017Article
- Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma.Canadian respiratory journal · 2016Article
- Stress and Bronchodilator Response in Children with Asthma.American journal of respiratory and critical care medicine · 2015Article
- Fractional exhaled nitric oxide and impulse oscillometry in children with allergic rhinitis.Allergy, asthma & immunology research · 2014Article
- Practical approach to managing exercise-induced asthma in children and adults.Primary care respiratory journal : journal of the General Practice Airways Group · 2013Article
- Asthma outcomes: pulmonary physiology.The Journal of allergy and clinical immunology · 2012Review
- A study of the use of impulse oscillometry in the evaluation of children with asthma: analysis of lung parameters, order effect, and utility compared with spirometry.Pediatric pulmonology · 2012Article
- Assessment of bronchodilator responsiveness following methacholine-induced bronchoconstriction in children with asthma.Allergy, asthma & immunology research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the diagnostic accuracy of bronchodilator responsiveness for asthma in 5-10 year old children.
methodsSpirometric measurements were made in 142 children (58 wheezers) before and after 400 mug inhaled salbutamol.
resultsOn a receiver operating characteristic curve, a 9% increase in predicted forced expiratory volume in 1 second was the cut off point that provided an acceptable balance of sensitivity and specificity for previous wheeze. This figure was 50% (95% CI 38 to 62) sensitive and 86% (95% CI 78 to 92) specific for detecting previous wheeze and multiplied the initial odds in favour of wheeze by a factor of 3.6 (95% CI 2.0 to 6.3). DISCUSSION: With an estimated pretest probability of wheeze of 10% in the community and 50% in a specialist clinic, the positive predictive values are 29% and 78%, respectively, for a 9% change. The value of bronchodilator responsiveness testing depends on the prevalence of wheeze in the population in which it is to be used.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.