Evidence map›Paper›PMID 15618483›Full record

ReviewPhysiological reviews2005

Molecular diversity and regulation of renal potassium channels.

Steven C Hebert, Gary Desir, Gerhard Giebisch, Wenhui Wang

Open access · greenAbstract readReview
In one paragraph

Review in Physiological reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 316 citations in OpenAlex.

  1. Article
  2. Mechanistic target of rapamycin complex-2 mediates the effect of overnight high KAmerican journal of physiology. Renal physiology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Role of calcineurin in regulating renal potassium (KActa physiologica (Oxford, England) · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. KBiomedicines · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. The effect of high-dietary KFrontiers in physiology · 2022
    Article
  17. Article
  18. Unappreciated Roles for KTrends in microbiology · 2021
    Review
  19. Review
  20. Review

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Steven C HebertDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520-8026, USA. steven.hebert@yale.edu
Gary Desir
Gerhard Giebisch
Wenhui Wang
Yale University · US

Funding

Vasoregulatory Function of CYP2E1-Derived EicosanoidsP01HL034300 · NHLBI · NEW YORK MEDICAL COLLEGE · PI JIANG, HOULI · 1985 to 2015
$33.4M
The Regulation of Renal Epithelial Cell Junction Assembly and PolarizationP01DK017433 · NIDDK · YALE UNIVERSITY · PI FORBUSH, BLISS · 1986 to 2018
$29.5M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
STRUCTURE AND FUNCTION OF ROMK CHANNEL IN KIDNEYR01DK054999 · NIDDK · YALE UNIVERSITY · PI WANG, TONG WANG · 2001 to 2008
$3.2M
MODULATION OF K+ CHANNELS IN RENAL COLLECTING DUCTR01DK047402 · NIDDK · NEW YORK MEDICAL COLLEGE · PI WANG, WENHUI · 1999 to 2007
$2.3M
Structure, Function and Regulation of Renal K ChannelsR01DK048105 · NIDDK · YALE UNIVERSITY · PI DESIR, GARY V. · 1994 to 2005
$1.6M
Regulation of Glucose Homeostasis by the Kv1.3 ChannelR01DK065172 · NIDDK · YALE UNIVERSITY · PI DESIR, GARY V. · 2004 to 2008
$1.3M
ROMK CHANNEL FUNCTION AND REGULATION IN KIDNEYR01DK054998 · NIDDK · YALE UNIVERSITY · PI GIEBISCH, GERHARD H · 1999 to 2003
$883k
Role of Kir4.1 in Regulating NCC and ROMK in DCTR56DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2021 to 2021
$100k
MODULATION OF K+ CHANNELS IN RENAL COLLECTING DUCTR29DK047402 · NIDDK · NEW YORK MEDICAL COLLEGE · PI WANG, WEN-HUI · 1994 to 1998
–
NHLBI NIH HHS HL-34300NHLBI NIH HHS P01 HL034300NIDDK NIH HHS DK-065172-01NIDDK NIH HHS DK-17433NIDDK NIH HHS DK-17433-30NIDDK NIH HHS DK-47402NIDDK NIH HHS DK-48105-08NIDDK NIH HHS DK-54983NIDDK NIH HHS DK-54998NIDDK NIH HHS DK-54999NIDDK NIH HHS P01 DK017433NIDDK NIH HHS R01 DK047402NIDDK NIH HHS R01 DK048105NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R01 DK054998NIDDK NIH HHS R01 DK054999NIDDK NIH HHS R01 DK065172NIDDK NIH HHS R56 DK054983
6 · The paper itself

Abstract

K(+) channels are widely distributed in both plant and animal cells where they serve many distinct functions. K(+) channels set the membrane potential, generate electrical signals in excitable cells, and regulate cell volume and cell movement. In renal tubule epithelial cells, K(+) channels are not only involved in basic functions such as the generation of the cell-negative potential and the control of cell volume, but also play a uniquely important role in K(+) secretion. Moreover, K(+) channels participate in the regulation of vascular tone in the glomerular circulation, and they are involved in the mechanisms mediating tubuloglomerular feedback. Significant progress has been made in defining the properties of renal K(+) channels, including their location within tubule cells, their biophysical properties, regulation, and molecular structure. Such progress has been made possible by the application of single-channel analysis and the successful cloning of K(+) channels of renal origin.

Indexed as

AnimalsHumansKidneyKidney DiseasesPotassium ChannelsProtein Structure, TertiaryPotassium Channels

Identifiers

PMID15618483
PMCPMC2838721
OpenAlexW2032063322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.