ArticleProceedings of the National Academy of Sciences of the United States of America2005
Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Glutaminase activity maintains NK cell cytotoxicity through metabolic regulation of effector function.Journal of inflammation (London, England) · 2025Article
- Locked and Loaded: Mechanisms Regulating Natural Killer Cell Lytic Granule Biogenesis and Release.Frontiers in immunology · 2022Review
- Review
- Single Degranulations in NK Cells Can Mediate Target Cell Killing.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Emerging roles for TFEB in the immune response and inflammation.Autophagy · 2018Review
- Protein kinase C controls lysosome biogenesis independently of mTORC1.Nature cell biology · 2016Article
- ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56 dim CD16+ and CD56 bright CD16 dim/- natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.Journal of translational medicine · 2016Article
- Cell biological steps and checkpoints in accessing NK cell cytotoxicity.Immunology and cell biology · 2014Review
- The enlarged lysosomes in beige j cells result from decreased lysosome fission and not increased lysosome fusion.Traffic (Copenhagen, Denmark) · 2012Article
- Two modes of lytic granule fusion during degranulation by natural killer cells.Immunology and cell biology · 2011Article
- Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells.PloS one · 2010Article
- Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis.Cellular and molecular life sciences : CMLS · 2010Article
- Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses.Immunity · 2009Article
- The killer's kiss: the many functions of NK cell immunological synapses.Current opinion in cell biology · 2008Review
- Formation and function of the lytic NK-cell immunological synapse.Nature reviews. Immunology · 2008Review
- Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.The Journal of experimental medicine · 2007Article
- Activation, coactivation, and costimulation of resting human natural killer cells.Immunological reviews · 2006Review
- Tumor-priming converts NK cells to memory-like NK cells.OncoimmunologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells play important roles in defense against tumor, viral infection, and cell-mediated xenograft rejection through secretion of secretory lysosomes. In this study, we used high time-resolution membrane capacitance measurement and fluorescence-imaging techniques to study the biogenesis and exocytosis of secretory lysosomes in a human NK cell line. We demonstrated a high-affinity Ca(2+)-dependent exocytosis of secretory lysosomes, which is sensitized further after target-cell stimulation. Our data also suggest an unusual rapid and dramatic de novo formation of secretory lysosomes after target-cell recognition. The rapid biogenesis of secretory lysosomes was blocked by specific protein kinase C inhibitor but not by brefeldin A. We propose that target-cell recognition triggers rapid biogenesis and sensitization of secretory lysosomes in NK cells through activation of PKC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.