ArticleProceedings of the National Academy of Sciences of the United States of America2005
Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
139 citing papers in PubMed, 261 citations in OpenAlex.
- Molecular Detection of Anaplasma marginale in the Central Region of Venezuela: A PCR-based Assessment of the msp2 and msp5 Genes.Acta parasitologica · 2026Article
- Immuno-Informatics Design of Multi-Epitope Vaccine Candidate AgainstHealth science reports · 2026Article
- Adaptation ofmSphere · 2026Article
- Genetic Diversity of Theileria parva and Anaplasma spp. Isolated From Ticks Collected From Kiambu County, Kenya.BioMed research international · 2026Article
- Nomenclature, classification, and in-silico structural analysis of MSP1a variants of Anaplasma marginale.PloS one · 2026Article
- Generation of Population-Level Diversity inPathogens (Basel, Switzerland) · 2025Article
- Genomic characters ofEmerging microbes & infections · 2024Article
- Detection of Anaplasma and Ehrlichia bacteria in humans, wildlife, and ticks in the Amazon rainforest.Nature communications · 2024Article
- The Occurrence of Cattle Tick Fever in a Region of the Atlantic Forest on the Border with the Caatinga in Brazil.Animals : an open access journal from MDPI · 2023Article
- Immunization withVaccines · 2023Article
- Genomic Characteristics of Emerging Intraerythrocytic Anaplasma capra and High Prevalence in Goats, China.Emerging infectious diseases · 2023Article
- Temporal Dynamics ofMicroorganisms · 2023Article
- Unravelling the diversity ofCurrent research in microbial sciences · 2023Article
- Recent advances in genetic systems in obligate intracellular human-pathogenic bacteria.Frontiers in cellular and infection microbiology · 2023Review
- Molecular Detection of Tick-Borne Rickettsial Pathogens Associated with the Arabian Camel (Camelus dromedarius) in Riyadh and the Eastern Region, Saudi Arabia.Acta parasitologica · 2022Article
- Iron Reduction inInternational journal of molecular sciences · 2022Article
- Bovine Anaplasmosis: Will there ever be an almighty effective vaccine?Frontiers in veterinary science · 2022Review
- Both Coinfection and Superinfection Drive Complex Anaplasma marginale Strain Structure in a Natural Transmission Setting.Infection and immunity · 2021Article
- First Survey on the Presence and Distribution of Oxytetracycline-Resistance Genes in Anaplasma Species.Acta parasitologica · 2021Article
- Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle.Nature reviews. Microbiology · 2021Review
79 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
The rickettsia Anaplasma marginale is the most prevalent tick-borne livestock pathogen worldwide and is a severe constraint to animal health. A. marginale establishes lifelong persistence in infected ruminants and these animals serve as a reservoir for ticks to acquire and transmit the pathogen. Within the mammalian host, A. marginale generates antigenic variants by changing a surface coat composed of numerous proteins. By sequencing and annotating the complete 1,197,687-bp genome of the St. Maries strain of A. marginale, we show that this surface coat is dominated by two families containing immunodominant proteins: the msp2 superfamily and the msp1 superfamily. Of the 949 annotated coding sequences, just 62 are predicted to be outer membrane proteins, and of these, 49 belong to one of these two superfamilies. The genome contains unusual functional pseudogenes that belong to the msp2 superfamily and play an integral role in surface coat antigenic variation, and are thus distinctly different from pseudogenes described as byproducts of reductive evolution in other Rickettsiales.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.