ReviewBritish journal of sports medicine2005
Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans.
Review in British journal of sports medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01167478 (Neurophysiological Reserve), which is not on this map. Cited by 110 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurophysiological Reserve: Peripheral and Central Effects of Caffeine Manipulation
Who cites it
110 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review of molecular signaling in the muscle-brain-gut axis: exercise-induced myokines and microbial metabolites as key mediators.Molecular biology reports · 2026Pooled it
- Maltodextrin-Based Carbohydrate Oral Rinsing and Exercise Performance: Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Effects of Nutritional Interventions on Accuracy and Reaction Time with Relevance to Mental Fatigue in Sporting, Military, and Aerospace Populations: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Does Acute Fatigue Negatively Affect Intrinsic Risk Factors of the Lower Extremity Injury Risk Profile? A Systematic and Critical Review.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- L-Menthol mouth rinse or ice slurry ingestion during the latter stages of exercise in the heat provide a novel stimulus to enhance performance despite elevation in mean body temperature.European journal of applied physiology · 2018Trial
- Neuroinflammation, cortical activity, and fatiguing behaviour during self-paced exercise.Pflugers Archiv : European journal of physiology · 2018Trial
- Effects of a 4-week high-intensity interval training on pacing during 5-km running trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Trial
- Rationale and design of REWARD (revving-up exercise for sustained weight loss by altering neurological reward and drive): a randomized trial in obese endometrial cancer survivors.Contemporary clinical trials · 2014Trial
- The effects of carbohydrate intake and muscle glycogen content on self-paced intermittent-sprint exercise despite no knowledge of carbohydrate manipulation.European journal of applied physiology · 2012Trial
- Consistency of perceptual and metabolic responses to a laboratory-based simulated 4,000-m cycling time trial.European journal of applied physiology · 2011Trial
- Carbohydrate ingestion and pre-cooling improves exercise capacity following soccer-specific intermittent exercise performed in the heat.European journal of applied physiology · 2011Trial
- Rapidity of responding to a hypoxic challenge during exercise.European journal of applied physiology · 2009Trial
- Effect of oral administration of sodium bicarbonate on surface EMG activity during repeated cycling sprints.European journal of applied physiology · 2007Trial
- High-Intensity Exercise Performance as a Complex Adaptive System: An Integrative Review.Muscles (Basel, Switzerland) · 2026Review
- Energy Availability as a Neurocognitive Regulator of Endurance Performance: Integrating Metabolic, Perceptual, and Decision-Making Mechanisms-A Narrative Review.Sports (Basel, Switzerland) · 2026Review
- Physiological Responder Profiles and Fatigue Dynamics in Prolonged Cycling.Journal of functional morphology and kinesiology · 2025Article
- Influence of deception of task duration on the sex-specific physiological responses to RPE-clamp cycle ergometry.European journal of applied physiology · 2025Article
- Biomolecular Basis of Life.Metabolites · 2025Review
- Fractal correlation properties of heart rate variability and respiratory frequency as measures of endurance exercise durability.European journal of applied physiology · 2025Article
- Physical and technical performance in and after the worst-case scenario in matches of the Chinese Super League of soccer.Biology of sport · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue is hypothesised as being the result of the complex interaction of multiple peripheral physiological systems and the brain. In this new model, all changes in peripheral physiological systems such as substrate depletion or metabolite accumulation act as afferent signallers which modulate control processes in the brain in a dynamic, non-linear, integrative manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.