Trial reportThe Journal of physiology2005
H1 receptor-mediated vasodilatation contributes to postexercise hypotension.
Trial report in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 108 citations in OpenAlex.
- Histamine-receptor blockade does not influence the heavy-severe domain boundary and time to task failure in the severe domain during cycling exercise in adults.Physiological reports · 2025Trial
- Histamine is a molecular transducer of adaptation to endurance exercise training in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Trial
- Folic acid ingestion improves skeletal muscle blood flow during graded handgrip and plantar flexion exercise in aged humans.American journal of physiology. Heart and circulatory physiology · 2017Trial
- Trial
- Mast cell degranulation and de novo histamine formation contribute to sustained postexercise vasodilation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- A single dose of histamine-receptor antagonists before downhill running alters markers of muscle damage and delayed-onset muscle soreness.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Evidence of a broad histamine footprint on the human exercise transcriptome.The Journal of physiology · 2016Trial
- Trial
- Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans.Experimental physiology · 2015Trial
- RAAS polymorphisms alter the acute blood pressure response to aerobic exercise among men with hypertension.European journal of applied physiology · 2006Trial
- Recombinant human diamine oxidase prevents histamine-induced hypoxia, shock and death in guinea pigs.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Evidence of histamine release in response to both aerobic and resistance exercise: histamine metabolites as biomarkers.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Article
- Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy.Life (Basel, Switzerland) · 2024Review
- Indoor overheating: A review of vulnerabilities, causes, and strategies to prevent adverse human health outcomes during extreme heat events.Temperature (Austin, Tex.) · 2024Review
- Risk factors for the development of orthostatic hypotension during autologous stem cell transplant in patients with multiple myeloma.Leukemia & lymphoma · 2022Article
- Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache.Molecular and cellular biochemistry · 2022Review
- The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension.Nature communications · 2022Article
- Consistency of hemodynamic and autonomic mechanisms underlying post-exercise hypotension.Journal of human hypertension · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In normally active individuals, postexercise hypotension after a single bout of aerobic exercise is due to an unexplained peripheral vasodilatation. Histamine has been shown to be released during exercise and could contribute to postexercise vasodilatation via H1 receptors in the peripheral vasculature. The purpose of this study was to determine the potential contribution of an H1 receptor-mediated vasodilatation to postexercise hypotension. We studied 14 healthy normotensive men and women (ages 21.9 +/- 2.1 years) before and through to 90 min after a 60 min bout of cycling at 60% on randomized control and H1 receptor antagonist days (540 mg oral fexofenadine hydrochloride; Allegra). Arterial blood pressure (automated auscultation) and femoral blood flow (Doppler ultrasound) were measured in the supine position. Femoral vascular conductance was calculated as flow/pressure. Fexofenadine had no effect on pre-exercise femoral vascular conductance or mean arterial pressure (P > 0.5). At 30 min postexercise on the control day, femoral vascular conductance was increased (Delta+33.7 +/- 7.8%; P < 0.05 versus pre-exercise) while mean arterial pressure was reduced (Delta-6.5 +/- 1.6 mmHg; P < 0.05 versus pre-exercise). In contrast, at 30 min postexercise on the fexofenadine day, femoral vascular conductance was not elevated (Delta+10.7 +/- 9.8%; P = 0.7 versus pre-exercise) and mean arterial pressure was not reduced (Delta-1.7 +/- 1.2 mmHg; P = 0.2 versus pre-exercise). Thus, ingestion of an H1 receptor antagonist markedly reduces vasodilatation after exercise and blunts postexercise hypotension. These data suggest H1 receptor-mediated vasodilatation contributes to postexercise hypotension.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.