ArticleInfection and immunity2005
Vaccination with purified Dr Fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Bacterial adhesion strategies and countermeasures in urinary tract infection.Nature microbiology · 2025Review
- Progress toward a vaccine for extraintestinal pathogenicInfection and immunity · 2024Article
- Emerging Non-Antibiotic Options Targeting Uropathogenic Mechanisms for Recurrent Uncomplicated Urinary Tract Infection.International journal of molecular sciences · 2023Review
- Broad protective vaccination against systemic Escherichia coli with autotransporter antigens.PLoS pathogens · 2023Article
- The Diversity ofMicroorganisms · 2023Review
- UTI patients have pre-existing antigen-specific antibody titers against UTI vaccine antigens.Vaccine · 2019Article
- Nonantibiotic prevention and management of recurrent urinary tract infection.Nature reviews. Urology · 2018Review
- Adhesive Pili in UTI Pathogenesis and Drug Development.Pathogens (Basel, Switzerland) · 2016Review
- Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections.Microbiology spectrum · 2016Review
- Pathogenesis of human diffusely adhering Escherichia coli expressing Afa/Dr adhesins (Afa/Dr DAEC): current insights and future challenges.Clinical microbiology reviews · 2014Review
- Cellular immunity survey against urinary tract infection using pVAX/fimH cassette with mammalian and wild type codon usage as a DNA vaccine.Clinical and experimental vaccine research · 2014Article
- Preventing urinary tract infection: progress toward an effective Escherichia coli vaccine.Expert review of vaccines · 2012Review
- Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds.Nature reviews. Microbiology · 2011Review
- Host-pathogen interactions in urinary tract infection.Nature reviews. Urology · 2010Review
- Waging war against uropathogenic Escherichia coli: winning back the urinary tract.Infection and immunity · 2010Review
- Adhesive threads of extraintestinal pathogenic Escherichia coli.Gut pathogens · 2009Article
- Mucosal immunization with iron receptor antigens protects against urinary tract infection.PLoS pathogens · 2009Article
- Uropathogenic Escherichia coli outer membrane antigens expressed during urinary tract infection.Infection and immunity · 2007Article
- [Recurrent urinary tract infections in women. Virulence of pathogens and host reaction].Der Urologe. Ausg. A · 2006Review
- Vaccines against extraintestinal pathogenicGut microbesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.