ArticleInfection and immunity2005
Effect of inactivation of degS on Salmonella enterica serovar typhimurium in vitro and in vivo.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- The serine protease HtrA regulates Group B Streptococcus virulence and affects the host response to infection.PLoS pathogens · 2025Article
- Hypervesiculation Meets Sec-Targeting: Enhancing Heterologous Protein Loading inInternational journal of molecular sciences · 2025Article
- Genome-wide characterization of Salmonella Typhimurium genes required for the fitness under iron restriction.BMC genomic data · 2022Article
- Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria.Frontiers in cellular and infection microbiology · 2019Review
- Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response.Cellular and molecular life sciences : CMLS · 2013Review
- Article
- Membrane proteases in the bacterial protein secretion and quality control pathway.Microbiology and molecular biology reviews : MMBR · 2012Review
- Integrated stress responses in Salmonella.International journal of food microbiology · 2012Review
- The phage shock protein PspA facilitates divalent metal transport and is required for virulence of Salmonella enterica sv. Typhimurium.Molecular microbiology · 2010Article
- PepD participates in the mycobacterial stress response mediated through MprAB and SigE.Journal of bacteriology · 2010Article
- Comprehensive identification of Salmonella enterica serovar typhimurium genes required for infection of BALB/c mice.PLoS pathogens · 2009Article
- Acid stress activation of the sigma(E) stress response in Salmonella enterica serovar Typhimurium.Molecular microbiology · 2009Article
- The YfgL lipoprotein is essential for type III secretion system expression and virulence of Salmonella enterica Serovar Enteritidis.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The alternative sigma factor (RpoE sigma(E)) enables Salmonella enterica serovar Typhimurium to adapt to stressful conditions, such as oxidative stress, nutrient deprivation, and growth in mammalian tissues. Infection of mice by Salmonella serovar Typhimurium also requires sigma(E). In Escherichia coli, activation of the sigma(E) pathway is dependent on proteolysis of the anti-sigma factor RseA and is initiated by DegS. DegS is also important in order for E. coli to cause extraintestinal infection in mice. We constructed a degS mutant of the serovar Typhimurium strain SL1344 and compared its behavior in vitro and in vivo with those of its wild-type (WT) parent and an isogenic rpoE mutant. Unlike E. coli degS strains, the Salmonella serovar Typhimurium degS strain grew as well as the WT strain at 42 degrees C. The degS mutant survived very poorly in murine macrophages in vitro and was highly attenuated compared with the WT strain for both the oral and parenteral routes of infection in mice. However, the degS mutant was not as attenuated as the serovar Typhimurium rpoE mutant: 100- to 1,000-fold more degS bacteria than rpoE bacteria were present in the livers and spleens of mice 24 h after intraperitoneal challenge. In most assays, the rpoE mutant was more severely affected than the degS mutant and a sigma(E)-dependent reporter gene was more active in the degS mutant than the rpoE strain. These findings indicate that degS is important for activation of the sigma(E) pathway in serovar Typhimurium but that alternative pathways for sigma(E) activation probably exist.
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