ArticleInfection and immunity2005
A peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection.PLoS pathogens · 2013Trial
- Immunogenicity of a Fap2 peptide mimotope ofInfectious agents and cancer · 2018Article
- Phage display as a promising approach for vaccine development.Journal of biomedical science · 2016Review
- Selection of peptide mimics of HIV-1 epitope recognized by neutralizing antibody VRC01.PloS one · 2015Article
- Characterization and epitope mapping of the polyclonal antibody repertoire elicited by ricin holotoxin-based vaccination.Clinical and vaccine immunology : CVI · 2014Article
- Carbohydrate-mimetic peptides for pan anti-tumor responses.Frontiers in immunology · 2014Review
- Mimotope vaccination for epitope-specific induction of anti-VEGF antibodies.BMC biotechnology · 2013Article
- Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease.Journal of lipid research · 2012Article
- A serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibody requires Fcγ receptor III and macrophages to mediate protection against pneumococcal pneumonia in mice.Infection and immunity · 2012Article
- Potential of peptides as inhibitors and mimotopes: selection of carbohydrate-mimetic peptides from phage display libraries.Journal of nucleic acids · 2012Article
- Mimotopes selected with neutralizing antibodies against multiple subtypes of influenza A.Virology journal · 2011Article
- Characterization of gene use and efficacy of mouse monoclonal antibodies to Streptococcus pneumoniae serotype 8.Clinical and vaccine immunology : CVI · 2011Article
- Mimotopes selected with a neutralizing antibody against urease B from Helicobacter pylori induce enzyme inhibitory antibodies in mice upon vaccination.BMC biotechnology · 2010Article
- Aggregation of Streptococcus pneumoniae by a pneumococcal capsular polysaccharide-specific human monoclonal IgM correlates with antibody efficacy in vivo.Clinical and vaccine immunology : CVI · 2010Article
- Efficacy of opsonic and nonopsonic serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibodies against intranasal challenge with Streptococcus pneumoniae in mice.Infection and immunity · 2009Article
- A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Pneumococcal capsular polysaccharide vaccine-mediated protection against serotype 3 Streptococcus pneumoniae in immunodeficient mice.Infection and immunity · 2007Article
- Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice.Infection and immunity · 2007Article
- Maintenance of antigen-specific immunological memory through variable regions of heavy and light chains of anti-idiotypic antibody.Immunology · 2007Article
- Phage display in the study of infectious diseases.Trends in microbiology · 2006Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Increasing antibiotic resistance and a rising patient population at risk for infection due to impaired immunity underscore the importance of vaccination against pneumococci. However, available capsular polysaccharide vaccines are often poorly immunogenic in patients at risk for pneumococcal disease. The goal of this study was to explore the potential of peptide mimotopes to function as alternative vaccine antigens to elicit a type-specific antibody response to pneumococci. We used a human monoclonal immunoglobulin A (IgA) antibody (NAD) to type 8 Streptococcus pneumoniae capsular polysaccharide (type 8 PS) to screen a phage display library, and the phage PUB1 displaying the peptide FHLPYNHNWFAL was selected after three rounds of biopanning. Inhibition studies with phage-displayed peptide or the peptide PUB1 and type 8 PS showed that PUB1 is a mimetic of type 8 PS. PUB1 conjugated to tetanus toxoid (PUB1-TT) induced a type 8 PS-specific antibody response in BALB/c mice, further defining it as a mimotope of type 8 PS. The administration of immune sera obtained from PUB1-TT-immunized mice earlier (days 14 and 21) and later (days 87 and 100) after primary and reimmunization resulted in a highly significant prolongation of the survival of naive mice after pneumococcal challenge compared to controls. The survival of PUB1-TT-immunized mice was also prolonged after pneumococcal challenge nearly 4 months after primary immunization. The efficacy of PUB1-TT-induced immune sera provides proof of principle that a mimotope-induced antibody response can protect against pneumococci and suggests that peptide mimotopes selected by type-specific human antibodies could hold promise as immunogens for pneumococci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.