ArticleJournal of fluorescence2004
Glucose-sensitive nanoassemblies comprising affinity-binding complexes trapped in fuzzy microshells.
Article in Journal of fluorescence, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Preparation of Hydrogen Peroxide Sensitive Nanofilms by a Layer-by-Layer Technique.Nanomaterials (Basel, Switzerland) · 2018Article
- Recent Progress in Lectin-Based Biosensors.Materials (Basel, Switzerland) · 2015Review
- Concanavalin A-polysaccharides binding affinity analysis using a quartz crystal microbalance.Biosensors & bioelectronics · 2014Article
- Optimization of a Concanavalin A-based glucose sensor using fluorescence anisotropy.Analytical chemistry · 2013Article
- Glucose sensing by time-resolved fluorescence of sol-gel immobilized glucose oxidase.Sensors (Basel, Switzerland) · 2011Article
- Dissolved core alginate microspheres as "smart-tattoo" glucose sensors.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2009Article
- Experimental validation of an optical system for interrogation of dermally-implanted microparticle sensors.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2009Article
- Preclinical in vivo study of a fluorescence affinity sensor for short-term continuous glucose monitoring in a small and large animal model.Diabetes technology & therapeutics · 2008Article
- Glucose Determination by Means of Steady-state and Time-course UV Fluorescence in Free or Immobilized Glucose Oxidase.Sensors (Basel, Switzerland) · 2007Article
- Fiber-coupled fluorescence affinity sensor for 3-day in vivo glucose sensing.Journal of diabetes science and technology · 2007Article
- Microscale enzymatic optical biosensors using mass transport limiting nanofilms. 1. Fabrication and characterization using glucose as a model analyte.Analytical chemistry · 2007Article
- Microporated PEG spheres for fluorescent analyte detection.Journal of fluorescence · 2007Article
- Enzymatic fluorescent microsphere glucose sensors:evaluation of response under dynamic conditions.Diabetes technology & therapeutics · 2006Article
- Glucose sensors based on microcapsules containing an orange/red competitive binding resonance energy transfer assay.Diabetes technology & therapeutics · 2006Article
- A glucose-sensing contact lens: from bench top to patient.Current opinion in biotechnology · 2005Review
- Three-dimensional, multiwavelength Monte Carlo simulations of dermally implantable luminescent sensors.Journal of biomedical opticsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A new design for glucose monitoring with "smart" materials based on self assembly, competitive binding, and resonance energy transfer (RET) is presented. The basic transduction principle is changing RET efficiency from fluorescein isothiocyanate (FITC) to tetramethylrhodamine isothiocyanate (TRITC), as FITC-dextran is displaced from TRITC-Concanavalin A (Con A) with the addition of glucose. Nanoscale fabrication by self-assembly of Con A/dextran into multilayer films, followed by polymer multilayers. The advantages of this approach include physical localization and separation of sensing molecules from the environment via entrapment of the biosensorelements in a semi-permeable polymeric shell, and only functional molecules are included in the sensors. To realize these nanostructures, dissolvable resin microparticles were coated with FITC-dextran+TRITC-Con A multilayers, followed by polyelectrolyte multilayers, and the core particles were then dissolved to yield hollow capsules. The nanoassembly process was studied using microbalance mass measurements, fluorescence spectroscopy, confocal fluorescence microscopy, and zeta-potential measurements. The key findings are that the specific binding between Con A and dextran can be used to deposit ultrathin multilayer films, and these exhibit changing RET in response to glucose. Fluorescence spectra of a microcapsules exhibited a linear, glucose-specific, 27% increase in the relative fluorescence of FITC over the 0-1800 mg/dL range. These findings demonstrate the feasibility of using self-assembled microcapsules as optical glucose sensors, and serve as a basis for work toward better understanding the properties of these novel materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.