ArticleHistochemistry and cell biology2005
Expression of peroxisome proliferator-activated receptors in zebrafish (Danio rerio) depending on gender and developmental stage.
Article in Histochemistry and cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 84 citations in OpenAlex.
- Direct adverse effects of fipronil sulfone, diisopentyl phthalate and disperse red 60 on zebrafish hepatocytes.Toxicology reports · 2026Article
- Single-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio).Journal of hazardous materials · 2025Article
- Genetic Mechanism of Tissue-Specific Expression ofInternational journal of molecular sciences · 2022Article
- Zebrafish and Flavonoids: Adjuvants against Obesity.Molecules (Basel, Switzerland) · 2021Review
- Perfluorooctanesulfonic Acid-Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion.Environmental toxicology and chemistry · 2021Article
- Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling.Journal of developmental origins of health and disease · 2021Article
- Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARγ.Aquatic toxicology (Amsterdam, Netherlands) · 2020Article
- Obese zebrafish: A small fish for a major human health condition.Animal models and experimental medicine · 2018Review
- Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats.Neuropharmacology · 2018Article
- Cross platform analysis of transcriptomic data identifies ageing has distinct and opposite effects on tendon in males and females.Scientific reports · 2017Article
- In vivo imaging and quantification of regional adiposity in zebrafish.Methods in cell biology · 2017Review
- Ontogenetic development of adipose tissue in grass carp (Ctenopharyngodon idellus).Fish physiology and biochemistry · 2015Article
- Effects of lipid-lowering pharmaceutical clofibrate on lipid and lipoprotein metabolism of grass carp (Ctenopharyngodon idellal Val.) fed with the high non-protein energy diets.Fish physiology and biochemistry · 2015Article
- Article
- Peroxisome deficient invertebrate and vertebrate animal models.Frontiers in physiology · 2013Review
- Melatonin and peripheral circuitries: insights on appetite and metabolism in Danio rerio.Zebrafish · 2013Article
- Expression of developmental-stage-specific genes in the gilthead sea bream Sparus aurata L.Marine biotechnology (New York, N.Y.) · 2013Article
- Mechanisms regulating GLUT4 transcription in skeletal muscle cells are highly conserved across vertebrates.PloS one · 2013Article
- In vivo analysis of white adipose tissue in zebrafish.Methods in cell biology · 2011Article
- Peroxisomes in zebrafish: distribution pattern and knockdown studies.Histochemistry and cell biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peroxisome proliferator-activated receptors (PPARs) are members of the superfamily of nuclear hormone receptors involved in embryo development and differentiation of several tissues in mammals. The aim of the present study was to investigate the possible differential expression of the three PPAR subtypes (PPARalpha, PPARbeta, and PPARgamma) in relation to gender and developmental stage in zebrafish. For this purpose PPAR expression was assessed by immunohistochemistry in 7-day-old larvae, 1-month-old juveniles, and 1-year-old adults. Additionally, the activity of peroxisomal acyl-CoA oxidase (AOX), a gene regulated by PPARs, and the volume density of catalase-immunolabeled liver peroxisomes (V(VP)) was examined. No significant gender-related differences were detected in the tissue distribution of the three PPAR subtypes or in peroxisomal AOX activity and V(VP). The percentage of PPARbeta-positive hepatocytes was significantly higher in females than in males suggesting a specific regulatory role of this subtype in female zebrafish. The three PPAR subtypes were already expressed at the larval stage, with a similar tissue distribution pattern to that found in adults. For all stages, PPARalpha and PPARgamma were expressed at higher levels than PPARbeta, and PPARbeta immunolabeling was stronger in juveniles than in larval or adult stages. The percentages of hepatocyte nuclei immunolabeled for PPARs was higher in early developmental stages than in adults, similarly to AOX activity and V(VP). In conclusion, our results indicate that PPAR expression, the activity of its target gene AOX, and peroxisomal biogenesis are developmentally modulated in zebrafish.
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