ArticleJournal of cancer research and clinical oncology2005
New tumor necrosis factor-alpha-inducing protein released from Helicobacter pylori for gastric cancer progression.
Article in Journal of cancer research and clinical oncology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Outer Membrane Vesicles Mediate the Secretion and Nuclear Trafficking of a Bacterial Nucleomodulin.Journal of extracellular vesicles · 2026Article
- The TNF-Alpha Inducing Protein is Associated With Gastric Inflammation and Hyperplasia in a Murine Model ofFrontiers in pharmacology · 2022Article
- Prevalence of tumor necrosis factor alpha inducing protein (3 Biotech · 2021Article
- Role of TNF-α-Inducing Protein Secreted byToxins · 2021Review
- Review
- The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers.Journal of cancer research and clinical oncology · 2018Review
- The correlation between TNF-α-308 gene polymorphism and susceptibility to cervical cancer.Oncology letters · 2018Article
- Inhibition of TNFα-interacting protein α (Tipα)-associated gastric carcinogenesis by BTG2Experimental & molecular medicine · 2018Article
- Article
- Article
- Gene polymorphisms of pathogenicWorld journal of gastroenterology · 2016Review
- Inflammatory microenvironment contributes to epithelial-mesenchymal transition in gastric cancer.World journal of gastroenterology · 2016Review
- Effect ofExperimental and therapeutic medicine · 2016Article
- Understanding the dimorphic lifestyles of human gastric pathogen Helicobacter pylori using the SWATH-based proteomics approach.Scientific reports · 2016Article
- Helicobacter pylori protein JHP0290 exhibits proliferative and anti-apoptotic effects in gastric epithelial cells.PloS one · 2015Article
- Cell-surface nucleolin acts as a central mediator for carcinogenic, anti-carcinogenic, and disease-related ligands.Journal of cancer research and clinical oncology · 2014Article
- Functional genetic variants of TNFSF15 and their association with gastric adenocarcinoma: a case-control study.PloS one · 2014Article
- Tumor promoters: from chemicals to inflammatory proteins.Journal of cancer research and clinical oncology · 2013Review
- Helicobacter pylori tumor necrosis factor-α inducing protein promotes cytokine expression via nuclear factor-κB.World journal of gastroenterology · 2013Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the association between Helicobacter pylori infection and its inflammatory reaction in gastritis, gastric ulcer, and gastric cancer, a new tumor necrosis factor-alpha (TNF-alpha)-inducing protein of H. pylori was studied.
methodsThe HP0596 gene of H. pylori was identified as the TNF-alpha-inducing protein (Tipalpha) gene from genome sequence of H. pylori strain 26695. Using recombinant Tipalpha (rTipalpha) and deleted Tipalpha (rdel-Tipalpha) proteins, the latter of which lacks six amino acids containing two cysteines in the N-terminal domain, we examined their activities in TNF-alpha gene expression and NF-kappaB activation in both Bhas 42 (v-H-ras transfected BALB/3T3) cells and mouse gastric epithelial cell line MGT-40, and in vitro transformation of Bhas 42 cells.
resultsTipalpha protein as a homodimer form (38 kDa) was found in both extracts and culture medium of various H. pylori strains. rTipalpha significantly induced TNF-alpha gene expression and NF-kappaB activation in both Bhas 42 cells and MGT-40, and induced in vitro transformation of Bhas 42 cells. However, rdel-Tipalpha did not. Treatment with MG-132, a proteasome inhibitor, inhibited translocation of NF-kappaB p65, and abrogated TNF-alpha induction induced by Tipalpha protein.
conclusionTipalpha is a new carcinogenic factor released from H. pylori mediated through NF-kappaB activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.