ArticleThe EMBO journal2005
The VirE3 protein of Agrobacterium mimics a host cell function required for plant genetic transformation.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 119 citations in OpenAlex.
- Myosin VIII and XI isoforms interact with the Agrobacterium VirE2 protein and facilitate its transport from the plasma membrane to the perinuclear region during plant transformation.Plant communications · 2026Article
- Identification of candidate nucleomodulins in ESKAPE bacteria -Frontiers in cellular and infection microbiology · 2026Article
- DNA Transport through the Dynamic Type IV Secretion System.Infection and immunity · 2023Review
- Enhanced Synthesis of Foreign Nuclear Protein Stimulates Viral Reproduction via the Induction ofPlants (Basel, Switzerland) · 2022Article
- Genetic factors governing bacterial virulence and host plant susceptibility duringAdvances in genetics · 2022Review
- JAZ8 Interacts With VirE3 Attenuating Agrobacterium Mediated Root Tumorigenesis.Frontiers in plant science · 2021Article
- Article
- Maize NCP1 negatively regulates drought and ABA responses through interacting with and inhibiting the activity of transcription factor ABP9.Plant molecular biology · 2020Article
- Review
- Article
- Protein phosphatase 2A regulates the nuclear accumulation of the Arabidopsis bZIP protein VIP1 under hypo-osmotic stress.Journal of experimental botany · 2019Article
- Pathways of DNA Transfer to Plants fromAnnual review of phytopathology · 2019Article
- Calcium signalling regulates the functions of the bZIP protein VIP1 in touch responses in Arabidopsis thaliana.Annals of botany · 2018Article
- A new toolset for protein expression and subcellular localization studies in citrus and its application toPlant methods · 2018Article
- Network Analyses in Plant Pathogens.Frontiers in microbiology · 2018Review
- Agrobacterium-mediated plant transformation: biology and applications.The arabidopsis book · 2017Article
- VIP1 is very important/interesting protein 1 regulating touch responses of Arabidopsis.Plant signaling & behavior · 2016Article
- The bZIP Protein VIP1 Is Involved in Touch Responses in Arabidopsis Roots.Plant physiology · 2016Article
- Nopaline-type Ti plasmid of Agrobacterium encodes a VirF-like functional F-box protein.Scientific reports · 2015Article
- The Tomato yellow leaf curl virus (TYLCV) V2 protein inhibits enzymatic activity of the host papain-like cysteine protease CYP1.Biochemical and biophysical research communications · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To genetically transform plants, Agrobacterium exports its transferred DNA (T-DNA) and several virulence (Vir) proteins into the host cell. Among these proteins, VirE3 is the only one whose biological function is completely unknown. Here, we demonstrate that VirE3 is transferred from Agrobacterium to the plant cell and then imported into its nucleus via the karyopherin alpha-dependent pathway. In addition to binding plant karyopherin alpha, VirE3 interacts with VirE2, a major bacterial protein that directly associates with the T-DNA and facilitates its nuclear import. The VirE2 nuclear import in turn is mediated by a plant protein, VIP1. Our data indicate that VirE3 can mimic this VIP1 function, acting as an 'adapter' molecule between VirE2 and karyopherin alpha and 'piggy-backing' VirE2 into the host cell nucleus. As VIP1 is not an abundant protein, representing one of the limiting factors for transformation, Agrobacterium may have evolved to produce and export to the host cells its own virulence protein that at least partially complements the cellular VIP1 function necessary for the T-DNA nuclear import and subsequent expression within the infected cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.