ArticleAntimicrobial agents and chemotherapy2005
Analysis of the genetic variability of virulence-related loci in epidemic clones of methicillin-resistant Staphylococcus aureus.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Bacteriophage Resistance, Adhesin's and Toxin's Genes Profile ofMicroorganisms · 2025Article
- Accessory Gene Regulator (Frontiers in microbiology · 2022Article
- In Vitro Anti-Biofilm Activity of Bacteriophage K (ATCC 19685-B1) and Daptomycin against Staphylococci.Microorganisms · 2021Article
- Emergence of a mupirocin-resistant, methicillin-susceptible Staphylococcus aureus clone associated with skin and soft tissue infections in Greece.BMC microbiology · 2021Article
- Observational
- Characterization ofmSphere · 2019Article
- Distinct Phenotypic and Genomic Signatures Underlie Contrasting Pathogenic Potential ofFrontiers in microbiology · 2019Article
- Therapeutic Targeting of theFrontiers in microbiology · 2018Review
- Number of positive blood cultures, biofilm formation, and adhesin genes in differentiating true coagulase-negative staphylococci bacteremia from contamination.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Biofilm Morphotypes and Population Structure among Staphylococcus epidermidis from Commensal and Clinical Samples.PloS one · 2016Article
- Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB.Infection and immunity · 2015Article
- Whole-genome sequencing for high-resolution investigation of methicillin-resistant Staphylococcus aureus epidemiology and genome plasticity.Journal of clinical microbiology · 2014Article
- Longitudinal genetic analyses of Staphylococcus aureus nasal carriage dynamics in a diverse population.BMC infectious diseases · 2013Article
- A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.Genome research · 2013Article
- Occurrence of methicillin resistant Staphylococcus aureus (MRSA) among clinical samples in tehran-iran and its correlation with polymorphism of specific accessory gene regulator (AGR) groups.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Evolutionary analyses of Staphylococcus aureus identify genetic relationships between nasal carriage and clinical isolates.PloS one · 2011Article
- Predominance and emergence of clones of hospital-acquired methicillin-resistant Staphylococcus aureus in Malaysia.Journal of clinical microbiology · 2010Article
- High-throughput typing of Staphylococcus aureus by amplified fragment length polymorphism (AFLP) or multi-locus variable number of tandem repeat analysis (MLVA) reveals consistent strain relatedness.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Comparison of adhesion and virulence of two predominant hospital-acquired methicillin-resistant Staphylococcus aureus clones and clonal methicillin-susceptible S. aureus isolates.Infection and immunity · 2008Article
- Comparison of single- and multilocus sequence typing and toxin gene profiling for characterization of methicillin-resistant Staphylococcus aureus.Journal of clinical microbiology · 2007Article
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4 authors.
Funding
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Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) isolates have previously been classified into major epidemic clonal types by pulsed-field gel electrophoresis in combination with multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec typing. We aimed to investigate whether genetic variability in potentially polymorphic domains of virulence-related factors could provide another level of differentiation in a diverse collection of epidemic MRSA clones. The target regions of strains representative of epidemic clones and genetically related methicillin-susceptible S. aureus isolates from the 1960s that were sequenced included the R domains of clfA and clfB; the D, W, and M regions of fnbA and fnbB; and three regions in the agr operon. Sequence variation ranged from very conserved regions, such as those for RNAIII and the agr interpromoter region, to the highly polymorphic R regions of the clf genes. The sequences of the clf R domains could be grouped into six major sequence types on the basis of the sequences in their 3' regions. Six sequence types were also observed for the fnb sequences at the amino acid level. From an evolutionary point of view, it was interesting that a small DNA stretch at the 3' clf R-domain sequence and the fnb sequences agreed with the results of MLST for this set of strains. In particular, clfB R-domain sequences, which had a high discriminatory capacity and with which the types distinguished were congruent with those obtained by other molecular typing methods, have potential for use for the typing of S. aureus. Clone- and strain-specific sequence motifs in the clf and fnb genes may represent useful additions to a typing methodology with a DNA array.
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