ArticleAntimicrobial agents and chemotherapy2005
Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-{beta}-lactamase from different Italian hospitals.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Carbapenemase-producing bacteria in food-producing animals, wildlife and environment: A challenge for human health.Italian journal of food safety · 2019Article
- Tn6249, a new Tn6162 transposon derivative carrying a double-integron platform and involved with acquisition of the blaVIM-1 metallo-β-lactamase gene in Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy · 2015Article
- Characterization of the core and accessory genomes of Pseudomonas aeruginosa using bioinformatic tools Spine and AGEnt.BMC genomics · 2014Article
- Integrons: past, present, and future.Microbiology and molecular biology reviews : MMBR · 2014Review
- Article
- Molecular characterization of blaNDM-1 in a sequence type 235 Pseudomonas aeruginosa isolate from France.Antimicrobial agents and chemotherapy · 2013Article
- Molecular characterization of Achromobacter isolates from cystic fibrosis and non-cystic fibrosis patients in Madrid, Spain.Journal of clinical microbiology · 2013Article
- Isolation from a nonclinical sample of Leclercia adecarboxylata producing a VIM-1 metallo-β-lactamase.Antimicrobial agents and chemotherapy · 2013Article
- Diverse mobilized class 1 integrons are common in the chromosomes of pathogenic Pseudomonas aeruginosa clinical isolates.Antimicrobial agents and chemotherapy · 2012Article
- VIM-1-producing Pseudomonas mosselii isolates in Italy, predating known VIM-producing index strains.Antimicrobial agents and chemotherapy · 2012Article
- The accessory genome of Pseudomonas aeruginosa.Microbiology and molecular biology reviews : MMBR · 2010Review
- Dispersal of carbapenemase blaVIM-1 gene associated with different Tn402 variants, mercury transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy · 2010Article
- Tn6060, a transposon from a genomic island in a Pseudomonas aeruginosa clinical isolate that includes two class 1 integrons.Antimicrobial agents and chemotherapy · 2009Article
- Pseudomonas aeruginosa population structure revisited.PloS one · 2009Article
- Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2009Article
- Molecular epidemiology of outbreak-related pseudomonas aeruginosa strains carrying the novel variant blaVIM-17 metallo-beta-lactamase gene.Antimicrobial agents and chemotherapy · 2009Article
- The evolution of class 1 integrons and the rise of antibiotic resistance.Journal of bacteriology · 2008Article
- Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital.Antimicrobial agents and chemotherapy · 2007Article
- Rapid detection and identification of metallo-beta-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis.Journal of clinical microbiology · 2007Article
- blaVIM-2 and blaVIM-7 carbapenemase-producing Pseudomonas aeruginosa isolates detected in a tertiary care medical center in the United States: report from the MYSTIC program.Journal of clinical microbiology · 2007Article
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10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three epidemiologically independent Pseudomonas aeruginosa isolates, representative of the first VIM-1 metallo-beta-lactamase producers detected at three different hospitals in northern Italy, were investigated to determine their genomic relatedness and to compare the structures of the genetic supports for the VIM-1 determinants. The three isolates, all of serotype O11, appeared to be clonally related according to the results of genotyping by macrorestriction analysis of genomic DNA by pulsed-field gel electrophoresis and random amplification of polymorphic DNA. Investigation of the genetic support for the bla(VIM-1) determinant revealed that it was carried on identical or almost identical integrons (named In70.2 and In70.3) located within a conserved genomic context. The integrons were structurally related to In70 and In110, two plasmid-borne bla(VIM-1)-containing integrons from Achromobacter xylosoxidans and Pseudomonas putida isolates, respectively, from the same geographic area (northern Italy) and were found to be inserted close to the res site of a Tn5051-like transposon, different from any of those described previously, that was apparently carried on the bacterial chromosome. The present findings suggest that the three VIM-1-producing isolates are members of the same clonal complex which have been spreading in hospitals in northern Italy since the late 1990s and point to a common ancestry of their bla(VIM-1)-containing integrons.
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