ArticleMolecular biology of the cell2005
Phospholipase D is involved in myogenic differentiation through remodeling of actin cytoskeleton.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- The dynamic regulatory network of phosphatidic acid metabolism: a spotlight on substrate cycling between phosphatidic acid and diacylglycerol.Biochemical Society transactions · 2024Review
- Proximity Tagging Identifies the Glycan-Mediated Glycoprotein Interactors of Galectin-1 in Muscle Stem Cells.ACS chemical biology · 2021Article
- Syntrophins entangled in cytoskeletal meshwork: Helping to hold it all together.Cell proliferation · 2019Review
- Article
- Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells.The Journal of biological chemistry · 2016Article
- Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regeneration.Molecular biology of the cell · 2015Article
- Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer.Pharmacological reviews · 2014Review
- The role of phospholipase D1 in liver fibrosis induced by dimethylnitrosamine in vivo.Digestive diseases and sciences · 2014Article
- Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.Cell communication and signaling : CCS · 2013Article
- Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction.PloS one · 2013Article
- Phospholipase D signaling mediates reactive oxygen species-induced lung endothelial barrier dysfunction.Pulmonary circulation · 2013Article
- PLD1 Negatively Regulates Dendritic Branching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Annexin A1 induces skeletal muscle cell migration acting through formyl peptide receptors.PloS one · 2012Article
- Disruption of the phospholipase D gene attenuates the virulence of Aspergillus fumigatus.Infection and immunity · 2012Article
- The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).Cellular signalling · 2011Review
- Cortactin, an actin binding protein, regulates GLUT4 translocation via actin filament remodeling.Biochemistry. Biokhimiia · 2011Article
- Skeletal muscle regeneration in mice is stimulated by local overexpression of V1a-vasopressin receptor.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.The Journal of biological chemistry · 2011Article
- Article
- ADP-ribosylation factor 6 regulates mammalian myoblast fusion through phospholipase D1 and phosphatidylinositol 4,5-bisphosphate signaling pathways.Molecular biology of the cell · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the role of phospholipase D (PLD) and its product phosphatidic acid (PA) in myogenic differentiation of cultured L6 rat skeletal myoblasts. Arginine-vasopressin (AVP), a differentiation inducer, rapidly activated PLD in a Rho-dependent way, as shown by almost total suppression of activation by C3 exotoxin pretreatment. Addition of 1-butanol, which selectively inhibits PA production by PLD, markedly decreased AVP-induced myogenesis. Conversely, myogenesis was potentiated by PLD1b isoform overexpression but not by PLD2 overexpression, establishing that PLD1 is involved in this process. The expression of the PLD isoforms was differentially regulated during differentiation. AVP stimulation of myoblasts induced the rapid formation of stress fiber-like actin structures (SFLSs). 1-Butanol selectively inhibited this response, whereas PLD1b overexpression induced SFLS formation, showing that it was PLD dependent. Endogenous PLD1 was located at the level of SFLSs, and by means of an intracellularly expressed fluorescent probe, PA was shown to be accumulated along these structures in response to AVP. In addition, AVP induced a PLD-dependent neosynthesis of phosphatidylinositol 4,5-bisphosphate (PIP2), which also was accumulated along actin fibers. These data support the hypothesis that PLD participates in myogenesis through PA- and PIP2-dependent actin fiber formation.
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