ArticleProceedings of the National Academy of Sciences of the United States of America2005
Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Phase II trial of docetaxel with rapid androgen cycling for progressive noncastrate prostate cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008Trial
- Anti gC1qR/p32/HABP1 Antibody Therapy Decreases Tumor Growth in an Orthotopic Murine Xenotransplant Model of Triple Negative Breast Cancer.Antibodies (Basel, Switzerland) · 2020Article
- Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment.PLoS genetics · 2019Article
- Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells.Human reproduction (Oxford, England) · 2013Article
- p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation.The Journal of biological chemistry · 2012Article
- p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process.BMC cancer · 2010Article
- Article
- Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.Oncogene · 2009Article
- SV40 reporter viruses.Journal of virological methods · 2008Article
- DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.Cancer research · 2008Article
- Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1).The EMBO journal · 2007Article
- Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.Molecular and cellular biology · 2007Article
- Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis.Cell cycle (Georgetown, Tex.) · 2007Article
- ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.Oncogene · 2006Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Reduced p27 levels correlate with poor prognosis in a wide spectrum of human tumors and can accelerate tumorigenesis in mouse tissues. To determine whether p27 deficiency can accelerate tumorigenesis in tissues with inactive Rb and p53 pathways, we examined the effect of p27 status on prostate tumorigenesis in mice expressing simian virus 40 large T antigen (LT). In p27-deficient mice expressing LT, tumors progressed from high-grade prostatic intraepithelial neoplasia to poorly differentiated carcinoma at a greatly accelerated rate. p27 deficiency could not collaborate with a mutant of LT that fails to inactivate the Rb pathway alone. Furthermore, p27 deficiency does not increase the proliferation index, reduce the apoptotic index, or affect the expression of E2F-dependent genes in cells expressing LT at any stage of the disease. Expression of LT alone leads to maximal proliferation, but p27 deficiency still increases the amount of cyclin A and cyclin-dependent kinase 2-associated kinase activity in tissues. Interestingly, this model recapitulates an important feature of the human disease, specifically a high frequency of allelic loss of chromosome 16q, which is syntenic to mouse chromosome 8. Loss of heterozygosity may accelerate the inactivation of other tumor suppressors, such as E-cadherin, which are located in this interval. These experiments provide direct physiological and causal evidence that p27 has tumor suppressive functions independent of its role regulating cell proliferation.
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