Trial reportThe British journal of ophthalmology2005
Effect of nimodipine on ocular blood flow and colour contrast sensitivity in patients with normal tension glaucoma.
Trial report in The British journal of ophthalmology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 57 citations in OpenAlex.
- New trends in the treatment of open-angle glaucoma: a critical review.International ophthalmology · 2025Review
- An L-type calcium channel blocker nimodipine exerts anti-fibrotic effects by attenuating TGF-β1 induced calcium response in an in vitro model of thyroid eye disease.Eye and vision (London, England) · 2024Article
- L- and T-type CaNeural regeneration research · 2023Article
- Efficacy of Nimodipine Combined with Latanoprost in Treating Open-Angle Glaucoma and Its Influence on Ocular Hemodynamics and Visual Field Defects.Drug design, development and therapy · 2022Article
- Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.Nature communications · 2017Article
- Nimodipine Ophthalmic Formulations for Management of Glaucoma.Pharmaceutical research · 2017Article
- New directions in the treatment of normal tension glaucoma.Indian journal of ophthalmology · 2014Review
- Effects of antiglaucoma drugs on blood flow of optic nerve heads and related structures.Japanese journal of ophthalmology · 2013Review
- Glaucomatous optic neuropathy management: the role of neuroprotective agents.Medical hypothesis, discovery & innovation ophthalmology journal · 2013Review
- Current primary open-angle glaucoma treatments and future directions.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Glutamate-induced internalization of Ca(v)1.3 L-type Ca(2+) channels protects retinal neurons against excitotoxicity.The Journal of physiology · 2010Article
- Role of ocular blood flow in normal tension glaucoma.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of oral nimodipine on ocular haemodynamic parameters and colour contrast sensitivity in patients with normal tension glaucoma (NTG).
designThe study was performed in a randomised, placebo controlled, double masked, crossover design.
participantsNimodipine (60 mg) or placebo was administered to 14 consecutive NTG patients.
methodsThe effects or oral nimodipine or placebo on ocular and systemic haemodynamic parameters and colour contrast sensitivity along the tritan axis were studied two hours after administration. Optic nerve head blood flow (ONHBF) and choroidal blood flow (CHBF) were assessed with laser Doppler flowmetry. Ocular fundus pulsation amplitude (FPA) was measured with laser interferometry. Colour contrast sensitivity (CCS) was determined along the tritan colour axis.
main outcome measuresONHBF, CHBF, FPA, intraocular pressure and CCS were assessed in patients with NTG.
resultsMean ocular FPA increased by 14% (SD 14%) (p = 0.0008), ONHBF by 18% (SD 16%) (p = 0.0031), and CHBF by 12% (SD 14%) (p<0.001) after administration of nimodipine. Nimodipine also decreased the threshold of colour contrast sensitivity along the tritan colour axis (-14% (SD 12%); p = 0.048). However, individual changes in FPA, ONHBF, or CHBF were not correlated with changes in threshold of CCS along the tritan colour axis.
conclusionsThe results indicate that nimodipine increases ONH and choroidal blood flow in NTG patients and improves CCS. The latter effect does not, however, seem to be a direct consequence of the blood flow improvement.
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