ArticleJournal of molecular histology2004
Molecular morphology of neuronal apoptosis: analysis of caspase 3 activation during postnatal development of mouse cerebellar cortex.
Article in Journal of molecular histology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- A novel apoptosis probe, cyclic ApoPep-1, for in vivo imaging with multimodal applications in chronic inflammatory arthritis.Apoptosis : an international journal on programmed cell death · 2021Article
- Caspase-3 Mediated Cell Death in the Normal Development of the Mammalian Cerebellum.International journal of molecular sciences · 2018Review
- Ex vivo imaging of active caspase 3 by a FRET-based molecular probe demonstrates the cellular dynamics and localization of the protease in cerebellar granule cells and its regulation by the apoptosis-inhibiting protein survivin.Molecular neurodegeneration · 2016Article
- Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats.Journal of molecular histology · 2014Article
- Cell death atlas of the postnatal mouse ventral forebrain and hypothalamus: effects of age and sex.The Journal of comparative neurology · 2013Article
- Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Selection of reference genes for quantitative real-time RT-PCR studies in mouse brain.Journal of molecular neuroscience : MN · 2009Article
- Effects of maternal antenatal glucocorticoid treatment on apoptosis in the ovine fetal cerebral cortex.Journal of neuroscience research · 2009Article
- Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Region-specific interrelations between apoptotic proteins expression and DNA fragmentation in the neonatal rat brain.Neurochemical research · 2006Article
- Strategies to investigate gene expression and function in granule cells.Cerebellum (London, England) · 2005Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used the mammalian post-natal cerebellar cortex as a model to dissect out the molecular morphology of neuronal apoptosis in a well-defined population of central neurons: the cerebellar granule cells. By immunocytochemistry, in situ labeling of apoptotic cells, and analysis of cerebellar slices following particle-mediated gene transfer (biolistics), we have studied the relationship of cell death and cleavage of caspase 3, a key molecule in the execution of apoptosis, and monitored caspase 3 activation in living cells. Our results demonstrate the existence of caspase dependent and independent apoptotic pathways affecting the cerebellar granule cells at different stages of their life. Apoptosis of proliferating precursors and young pre-migratory cells occurs in the absence of caspase 3 cleavage, whereas cell death of post-mitotic post-migratory neurons is directly linked to caspase 3 activation. Data obtained from cerebellar cortex can be generalized to outline a more comprehensive picture of the cellular and molecular mechanisms of neuronal death not only in development, but also in a number of pathological conditions leading to neuronal loss.
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