ArticleBiophysical journal2005
Membrane lateral mobility obstructed by polymer-tethered lipids studied at the single molecule level.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 166 citations in OpenAlex.
- Effects of Macromolecular Crowding on the Structure and Dynamics of Biological Membranes.Sub-cellular biochemistry · 2025Review
- Supported Biomembrane Systems Incorporating Multiarm Polymers and Bioorthogonal Tethering.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Experimentally Probing the Effect of Confinement Geometry on Lipid Diffusion.The journal of physical chemistry. B · 2024Article
- Subdiffusive-Brownian crossover in membrane proteins: a generalized Langevin equation-based approach.Biophysical journal · 2021Article
- Substrate-supported Model Membrane as a Versatile Analytical/Biosensing Platform.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- Physical modeling of multivalent interactions in the nuclear pore complex.Biophysical journal · 2021Article
- Chitosan-covered liposomes as a promising drug transporter: nanoscale investigations.RSC advances · 2021Article
- Membrane-mediated amyloid deposition of human islet amyloid polypeptide.Biophysical reviews · 2018Review
- Changes in Cholesterol Level Alter Integrin Sequestration in Raft-Mimicking Lipid Mixtures.Biophysical journal · 2018Article
- A flow cytometry assay to quantify intercellular exchange of membrane components.Chemical science · 2017Article
- Oriented Membrane Protein Reconstitution into Tethered Lipid Membranes for AFM Force Spectroscopy.Biophysical journal · 2016Article
- Monte Carlo simulations of protein micropatterning in biomembranes: effects of immobile sticky obstacles.Journal of physics D: Applied physics · 2016Article
- Review
- MreB-Dependent Organization of the E. coli Cytoplasmic Membrane Controls Membrane Protein Diffusion.Biophysical journal · 2016Article
- Extracting Diffusive States of Rho GTPase in Live Cells: Towards In Vivo Biochemistry.PLoS computational biology · 2015Article
- GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane.Nature communications · 2015Article
- Tracking surface glycans on live cancer cells with single-molecule sensitivity.Angewandte Chemie (International ed. in English) · 2015Article
- Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures.Biophysical journal · 2014Article
- Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate.Biomaterials · 2014Article
- Bilayer asymmetry influences integrin sequestering in raft-mimicking lipid mixtures.Biophysical journal · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Obstructed long-range lateral diffusion of phospholipids (TRITC-DHPE) and membrane proteins (bacteriorhodopsin) in a planar polymer-tethered 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayer is studied using wide-field single molecule fluorescence microscopy. The obstacles are well-controlled concentrations of hydrophobic lipid-mimicking dioctadecylamine moieties in the polymer-exposed monolayer of the model membrane. Diffusion of both types of tracer molecules is well described by a percolating system with different percolation thresholds for lipids and proteins. Data analysis using a free area model of obstructed lipid diffusion indicates that phospholipids and tethered lipids interact via hard-core repulsion. A comparison to Monte Carlo lattice calculations reveals that tethered lipids act as immobile obstacles, are randomly distributed, and do not self-assemble into large-scale aggregates for low to moderate tethering concentrations. A procedure is presented to identify anomalous subdiffusion from tracking data at a single time lag. From the analysis of the cumulative distribution function of the square displacements, it was found that TRITC-DHPE and W80i show normal diffusion at lower concentrations of tethered lipids and anomalous diffusion at higher ones. This study may help improve our understanding of how lipids and proteins in biomembranes may be obstructed by very small obstacles comprising only one or very few molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.