ArticleBMC medical genetics2004
Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD.
Article in BMC medical genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.Journal of psychiatry & neuroscience : JPN · 2009Pooled it
- Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Molecular psychiatry · 2007Pooled it
- Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response.Neuromolecular medicine · 2013Trial
- COMT Val108/158Met polymorphism and the modulation of task-oriented behavior in children with ADHD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Trial
- The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder.Molecular psychiatry · 2022Article
- Facing the Methodological Challenge in Dissecting the Genetics of ADHD: A Case for Deep Phenotyping and Heterogeneity Reduction.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2020Article
- EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes.Brain topography · 2018Article
- Influence of the COMT val(108/158)met polymorphism on continuous performance task indices.Neuropsychologia · 2014Article
- The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD.Behavioral and brain functions : BBF · 2012Article
- Article
- Neuropsychological endophenotypes in attention-deficit/hyperactivity disorder: a review of genetic association studies.European archives of psychiatry and clinical neuroscience · 2011Review
- Neurobehavioral evidence for changes in dopamine system activity during adolescence.Neuroscience and biobehavioral reviews · 2010Review
- A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD.BMC psychiatry · 2008Article
- Interaction of dopamine system genes and cognitive functions in patients with schizophrenia and their relatives and in healthy subjects from the general population.Neuroscience and behavioral physiology · 2007Article
- The endophenotype concept in psychiatric genetics.Psychological medicine · 2007Review
- Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.CNS drug reviews · 2007Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Since several of the cognitive functions typically deficient in children with Attention Deficit Hyperactivity Disorder (ADHD) are mediated by prefrontal dopamine (DA) mechanisms, we investigated the relationship between a functional polymorphism of the COMT gene and neuropsychological task performance in these children.
methodsThe Val108/158 Met polymorphism of the COMT gene was genotyped in 118 children with ADHD (DSM-IV). The Wisconsin Card Sorting Test (WCST), Tower of London (TOL), and Self-Ordered Pointing Task (SOPT) were employed to evaluate executive functions. Neuropsychological task performance was compared across genotype groups using analysis of variance.
resultsADHD children with the Val/Val, Val/Met and Met/Met genotypes were similar with regard to demographic and clinical characteristics. No genotype effects were observed for WCST standardized perseverative error scores [F2,97 = 0.67; p > 0.05], TOL standardized scores [F2,99 = 0.97; p > 0.05], and SOPT error scores [F2,108 = 0.62; p > 0.05].
conclusionsContrary to the observed association between WCST performance and the Val108/158 Met polymorphism of the COMT gene in both healthy and schizophrenic adults, this polymorphism does not appear to modulate executive functions in children with ADHD.
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