ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2005
Unraveling the mechanism of the farnesyltransferase enzyme.
Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The evolving landscape of enzymatic technologies for precision synthesis of antibody-drug conjugates.Antibody therapeutics · 2026Review
- Theoretical Studies on Catalysis Mechanisms of Serum Paraoxonase 1 and Phosphotriesterase Diisopropyl Fluorophosphatase Suggest the Alteration of Substrate Preference from Paraoxonase to DFP.Molecules (Basel, Switzerland) · 2018Article
- Zinc-binding cysteines: diverse functions and structural motifs.Biomolecules · 2014Review
- Molecular dynamics analysis of a series of 22 potential farnesyltransferase substrates containing a CaaX-motif.Journal of molecular modeling · 2013Article
- Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.Biochemistry · 2012Article
- Metals in proteins: cluster analysis studies.Journal of molecular modeling · 2011Article
- Driven to death: Inhibition of farnesylation increases Ras activity and promotes growth arrest and cell death [corrected].Molecular cancer therapeutics · 2010Article
- The correlation of 113Cd NMR and 111mCd PAC spectroscopies provides a powerful approach for the characterization of the structure of Cd(II)-substituted Zn(II) proteins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2009Article
- Caged protein prenyltransferase substrates: tools for understanding protein prenylation.Chemical biology & drug design · 2008Article
- Computational studies of the farnesyltransferase ternary complex part I: substrate binding.Biochemistry · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Farnesyltransferase enzyme (FTase) is currently one of the most fascinating targets in cancer research. Studies in other areas, namely in the fight against parasites and viruses, have also led to very promising results. However, in spite of the thrilling achievements in the development of farnesyltransferase inhibitors (FTIs) over the past few years, the farnesylation mechanism remains, to some degree, a mystery. This review tries to shed some light on this puzzling enzyme by analyzing seven key mechanistic dilemmas, based on recent studies that have dramatically changed the way this enzyme is currently perceived.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.