ReviewMolecular psychiatry2005
Obsessive-compulsive disorder phenotypes: implications for genetic studies.
Review in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Evolution of gamma knife capsulotomy for intractable obsessive-compulsive disorder.Molecular psychiatry · 2019Pooled it
- Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2013Pooled it
- Meta-analysis of the symptom structure of obsessive-compulsive disorder.The American journal of psychiatry · 2008Pooled it
- Cariprazine-induced obsessive-compulsive symptoms in a patient with bipolar II disorder: A case report.Biomedical reports · 2026Article
- Acute Trauma and Obsessive Compulsive Disorder: Evidence from October 7th, 2023.Psychotherapy and psychosomatics · 2026Article
- Brain-Behavior Relationships: Neural Mechanisms of Impulsivity and Compulsivity in Neuropsychiatric Disorders.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2025Review
- Psychometric attributes of the Dimensional Yale-Brown Obsessive-Compulsive Scale adapted in Bengali: A validation study in the Bengali-speaking population.Indian journal of psychiatry · 2024Article
- Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families.Psychiatry research · 2024Article
- EPD1504: a novel μ-opioid receptor partial agonist attenuates obsessive-compulsive disorder (OCD)-like behaviors.Frontiers in psychiatry · 2023Article
- Suicidal Ideation and Obsessive-Compulsive Disorder: Links and Knowledge.Psychology research and behavior management · 2022Review
- A dimensional perspective on the genetics of obsessive-compulsive disorder.Translational psychiatry · 2021Review
- Symmetry Dimension in Obsessive-Compulsive Disorder: Prevalence, Severity and Clinical Correlates.Journal of clinical medicine · 2021Article
- Neurocognitive Endophenotypes of OCD.Current topics in behavioral neurosciences · 2021Article
- Bidirectional Behavioral Selection in Mice: A Novel Pre-clinical Approach to Examining Compulsivity.Frontiers in psychiatry · 2021Review
- Are There Familial Patterns of Symptom Dimensions in Obsessive-Compulsive Disorder?Frontiers in psychiatry · 2021Article
- Perceived Stress in Relation to Obsessions and Compulsions in South Asian Adults: Moderating Role of Socio-demographic Characteristics.Community mental health journal · 2020Article
- Inhibition-related differences between tic-free and tic-related obsessive-compulsive disorder: evidence from the N2 and P3.Experimental brain research · 2019Article
- Functional neural mechanisms of sensory phenomena in obsessive-compulsive disorder.Journal of psychiatric research · 2019Article
- OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency.Molecular psychiatry · 2018Article
- Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obsessive-compulsive disorder (OCD) clinical presentation is remarkably diverse, and can vary both within and across patients over time. This variability in the phenotypic expression has led to the hypothesis that OCD is a heterogeneous disorder and that this heterogeneity obscures the findings of clinical, natural history and treatment response studies and complicates the search for vulnerability genes. A complete understanding of what comprises OCD and the underlying etiological mechanisms will require a dramatic change in how the disorder is conceptualized. In this review, several different approaches that may represent the first steps in this reconceptualization are discussed. These approaches include (1) narrowing the phenotype to identify categorically defined more homogeneous and mutually exclusive subtypes of OCD, (2) considering OC symptom dimensions as quantitative components of the more complex OCD phenotype and (3) broadening the phenotype to include other etiologically related conditions. A combined dimensional approach within distinctive subgroups is proposed as probably the most effective in helping to identify the heritable components of OCD. By identifying heritable components of OCD, it should be possible to find genes for these separate components. The review continues with the illustration of the possible role of some epigenetic risk and protective factors in the OCD presentation and the relevance of examining associated traits and/or endophenotypes to enhance our ability to understand the genetic basis of OCD. To conclude, we discuss the variability in treatment outcome and the significance of the development of specific pharmacological and/or behavioral based therapies tailored to each of these phenotypes.
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Registered trials
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