ArticleRNA (New York, N.Y.)2005
Nuclear export of metazoan replication-dependent histone mRNAs is dependent on RNA length and is mediated by TAP.
Article in RNA (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- TREX-2 mRNA Export Complex Interacts with HLB Component FLASH and Is Recruited to Processed Histone mRNAs.Doklady. Biochemistry and biophysics · 2025Article
- TREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA.Doklady. Biochemistry and biophysics · 2024Article
- TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes.Nucleic acids research · 2020Article
- The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response.RNA (New York, N.Y.) · 2020Article
- Short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression: SINE-UP for active duty.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- ALYREF links 3'-end processing to nuclear export of non-polyadenylated mRNAs.The EMBO journal · 2019Article
- Circular RNA profiling provides insights into their subcellular distribution and molecular characteristics in HepG2 cells.RNA biology · 2019Article
- Two herpesviral noncoding PAN RNAs are functionally homologous but do not associate with common chromatin loci.PLoS pathogens · 2018Article
- Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs.Frontiers in genetics · 2018Review
- Guard the guardian: A CRL4 ligase stands watch over histone production.Nucleus (Austin, Tex.) · 2017Review
- MicroRNA-276 promotes egg-hatching synchrony by up-regulating brm in locusts.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A multiprotein occupancy map of the mRNP on the 3' end of histone mRNAs.RNA (New York, N.Y.) · 2015Article
- Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA.Retrovirology · 2014Article
- The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation.RNA (New York, N.Y.) · 2014Article
- Replication stress-induced alternative mRNA splicing alters properties of the histone RNA-binding protein HBP/SLBP: a key factor in the control of histone gene expression.Bioscience reports · 2013Article
- How cells get the message: dynamic assembly and function of mRNA-protein complexes.Nature reviews. Genetics · 2013Review
- Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.Molecular biology of the cell · 2013Article
- The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes.Genome biology · 2012Article
- Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.Molecular biology of the cell · 2011Article
- Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 4 countries.
Funding
Abstract
Replication-dependent histone mRNAs are the only metazoan mRNAs that are not polyadenylated, ending instead in a conserved stem-loop sequence. Histone pre-mRNAs lack introns and are processed in the nucleus by a single cleavage step, which produces the mature 3' end of the mRNA. We have systematically examined the requirements for the nuclear export of a mouse histone mRNA using the Xenopus oocyte system. Histone mRNAs were efficiently exported when injected as mature mRNAs, demonstrating that the process of 3' end cleavage is not required for export factor binding. Export also does not depend on the stem-loop binding protein (SLBP) since mutations of the stem-loop that prevent SLBP binding and competition with a stem-loop RNA did not affect export. Only the length of the region upstream of the stem-loop, but not its sequence, was important for efficient export. Histone mRNA export was blocked by competition with constitutive transport element (CTE) RNA, indicating that the mRNA export receptor TAP is involved in histone mRNA export. Consistent with this observation, depletion of TAP from Drosophila cells by RNAi resulted in the restriction of mature histone mRNAs to the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.