ArticleGenetics2004
Decreased diversity but increased substitution rate in host mtDNA as a consequence of Wolbachia endosymbiont infection.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 131 citations in OpenAlex.
- Article
- Article
- Phylogeographic analyses reveal recent dispersal and multiple Wolbachia infections of the bright-eyed ringlet Erebia oeme within the European mountain systems.Scientific reports · 2025Article
- Validating a Mitochondrial Sweep Accompanying the Rapid Spread of a Maternally Inherited Symbiont.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Mitochondrial genomes of soft scales (Hemiptera: Coccidae): features, structures and significance.BMC genomics · 2023Article
- Article
- Wolbachia-driven selective sweep in a range expanding insect species.BMC ecology and evolution · 2021Article
- Frequent Drivers, Occasional Passengers: Signals of Symbiont-Driven Seasonal Adaptation and Hitchhiking in the Pea Aphid,Insects · 2021Article
- Massive gene rearrangement in mitogenomes of phytoseiid mites.International journal of biological macromolecules · 2021Article
- Diversification, selective sweep, and body size in the invasive Palearctic alfalfa weevil infected with Wolbachia.Scientific reports · 2021Article
- Unveiling mosquito cryptic species and their reproductive isolation.Insect molecular biology · 2020Review
- Article
- Multiplex PCR for identification of two butterfly sister species: Eurema mandarina and Eurema hecabe.BMC research notes · 2020Article
- Global genetic diversity, lineage distribution, andEcology and evolution · 2019Article
- Prevalence and genetic diversity of Wolbachia endosymbiont and mtDNA in Palearctic populations of Drosophila melanogaster.BMC evolutionary biology · 2019Article
- Pyrosequencing Uncovers a Shift in Bacterial Communities Across Life Stages ofFrontiers in microbiology · 2019Article
- A phylogenetic examination of host use evolution in the quinaria and testacea groups of Drosophila.Molecular phylogenetics and evolution · 2019Article
- Fine-scale geographic patterns of gene flow and reproductive character displacement in Drosophila subquinaria and Drosophila recens.Molecular ecology · 2018Article
- Cryptic Plutella species show deep divergence despite the capacity to hybridize.BMC evolutionary biology · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A substantial fraction of insects and other terrestrial arthropods are infected with parasitic, maternally transmitted endosymbiotic bacteria that manipulate host reproduction. In addition to imposing direct selection on the host to resist these effects, endosymbionts may also have indirect effects on the evolution of the mtDNA with which they are cotransmitted. Patterns of mtDNA diversity and evolution were examined in Drosophila recens, which is infected with the endosymbiont Wolbachia, and its uninfected sister species D. subquinaria. The level of mitochondrial, but not nuclear, DNA diversity is much lower in D. recens than in D. subquinaria, consistent with the hypothesized diversity-purging effects of an evolutionarily recent Wolbachia sweep. The d(N)/d(S) ratio in mtDNA is significantly greater in D. recens, suggesting that Muller's ratchet has brought about an increased rate of substitution of slightly deleterious mutations. The data also reveal elevated rates of synonymous substitutions in D. recens, suggesting that these sites may experience weak selection. These findings show that maternally transmitted endosymbionts can severely depress levels of mtDNA diversity within an infected host species, while accelerating the rate of divergence among mtDNA lineages in different species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.