ArticleGenetics2004
Population genetics of the developmental gene optomotor-blind (omb) in Drosophila polymorpha: evidence for a role in abdominal pigmentation variation.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Co-evolving wing spots and mating displays are genetically separable traits in Drosophila.Evolution; international journal of organic evolution · 2020Article
- Quantifying Abdominal Pigmentation in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2017Article
- The Genetic Basis of Pigmentation Differences Within and Between Drosophila Species.Current topics in developmental biology · 2016Review
- A genome-wide, fine-scale map of natural pigmentation variation in Drosophila melanogaster.PLoS genetics · 2013Article
- The dynamics and evolutionary potential of domain loss and emergence.Molecular biology and evolution · 2012Article
- Convergent, modular expression of ebony and tan in the mimetic wing patterns of Heliconius butterflies.Development genes and evolution · 2011Article
- Article
- The genetic basis of adaptive pigmentation variation in Drosophila melanogaster.Molecular ecology · 2007Article
- Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea.Genetics · 2005Article
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Authors and funding
3 authors.
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Abstract
The developmental gene optomotor-blind (omb) encodes a T-box-containing transcription factor that has multiple roles in Drosophila development. Previous genetic analyses established that omb plays a key role in establishing the abdominal pigmentation pattern of Drosophila melanogaster. In this report we examine patterns of omb nucleotide variation in D. polymorpha, a species that is highly polymorphic for the phenotype of abdominal pigmentation. Haplotypes at this locus fall into two classes that are separated by six mutational steps; five of these mutational events result in amino acid changes. Two lines of evidence are consistent with a role for omb in the abdominal pigmentation polymorphism of D. polymorpha. First, we find that haplotype classes of omb are correlated with abdominal pigmentation phenotypes, as are microsatellite repeat numbers in the region. Second, tests of selection reveal that the two haplotype classes have been maintained by balancing selection. Within each class there is a significantly low amount of diversity, indicative of previous selective sweeps. An analysis including D. polymorpha's closest relatives (members of the cardini group) provides evidence for directional selection across species. Selection at this locus is expected if omb contributes to variation in abdominal pigmentation, since this trait is likely of ecological importance.
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