ArticleThe Journal of physiology2005
Central 5-HT7 receptors are critical for reflex activation of cardiac vagal drive in anaesthetized rats.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Vitamin D Supplementation during Winter: Effects on Stress Resilience in a Randomized Control Trial.Nutrients · 2020Trial
- Reduced anxiety in forensic inpatients after a long-term intervention with Atlantic salmon.Nutrients · 2014Trial
- Can Serotonin 7 Receptors Be a Treatment Target for Noncentral Diseases?The Eurasian journal of medicine · 2023Article
- Astrocytes Modulate Baroreflex Sensitivity at the Level of the Nucleus of the Solitary Tract.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Role of Serotonin in Singultus: A Review.Frontiers in neuroscience · 2020Review
- Article
- Activation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties.Brain research · 2016Article
- Decreased cardiac vagal control in drug-naïve patients with posttraumatic stress disorder.Psychiatry investigation · 2013Article
- Regional differences in serotonin content in the nucleus of the solitary tract of male rats after hypovolemia produced by polyethylene glycol.The journal of physiological sciences : JPS · 2013Article
- Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- 8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat.BMC neuroscience · 2010Article
- Peripheral 5-HT1A and 5-HT7 serotonergic receptors modulate parasympathetic neurotransmission in long-term diabetic rats.Experimental diabetes research · 2010Article
- Evidence that 5-hydroxytryptamine(7) receptors play a role in the mediation of afferent transmission within the nucleus tractus solitarius in anaesthetized rats.British journal of pharmacology · 2009Article
- Cardiac slowing and acute tryptophan depletion: a comment on the paper by van der Veen et al.Psychopharmacology · 2009Article
- Cold pressor test in the rat: medullary and spinal pathways and neurotransmitters.American journal of physiology. Heart and circulatory physiology · 2008Article
- 5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus.Neuropharmacology · 2008Article
- 5-HT(2) receptor subtypes mediate different long-term changes in GABAergic activity to parasympathetic cardiac vagal neurons in the nucleus ambiguus.Neuroscience · 2007Article
- Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications.Naunyn-Schmiedeberg's archives of pharmacology · 2007Review
- New insights into the electrophysiology of brainstem circuits controlling blood pressure.Current hypertension reports · 2007Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
5-Hydroxytryptamine (5-HT; serotonin)-containing neurones contribute to reflex activation of parasympathetic outflow in a number of species, but the 5-HT receptors mediating these effects have yet to be fully determined. The present experiments demonstrate that central 5-HT7 receptors are involved in the vagal bradycardia evoked during the cardiopulmonary reflex, baroreflexes and the chemoreflex, as well as other autonomic changes caused by these reflexes. The experiments examined the effects of the selective 5-HT7 receptor antagonists SB-269970 and SB-656104 on these reflexes. For the cardiopulmonary reflex, when compared to time-matched vehicle control experiments, intracisternal application of SB-269970 (30-300 microg kg(-1), i.c.) dose-dependently attenuated the evoked bradycardia. At the highest dose, SB-269970 also attenuated the reflex hypotension and sympathoinhibition. The structurally different 5-HT7 receptor antagonist SB-656104 (100 microg kg(-1), i.c.) similarly attenuated the reflex bradycardia and hypotension. SB-269970 (100 microg kg(-1), i.c.) also attenuated the bradycardias evoked by electrical stimulation of aortic nerve afferents and the baroreflex evoked by the pressor response to phenylephrine (3-25 microg kg(-1), i.v.). The gain of the baroreflex was also significantly attenuated (0.15 +/- 0.06 versus 0.34 +/- 0.06 ms mmHg(-1)). Finally, SB-269970 (100 microg kg(-1), i.c.) significantly attenuated both the bradycardia and sympathoexcitation evoked by the chemoreflex. These data indicate that central 5-HT7 receptors play an important facilitatory role in the reflex activation of vagal outflow to the heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.