ArticleThe Journal of physiology2005
Metabotropic glutamate receptor activity induces a novel oscillatory pattern in neonatal rat hypoglossal motoneurones.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- The Role of Calcium-Permeable Kainate and AMPA Receptors in the Leading Reaction of GABAergic Neurons to Excitation.Current issues in molecular biology · 2026Article
- Inspiratory-Activated Airway Vagal Preganglionic Neurones Excited by Thyrotropin-Releasing Hormone via Multiple Mechanisms in Neonatal Rats.Frontiers in physiology · 2018Article
- Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36.Cell death & disease · 2017Article
- Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons.The Journal of physiology · 2016Article
- Group I mGluRs evoke K-ATP current by intracellular Ca2+ mobilization in rat subthalamus neurons.The Journal of pharmacology and experimental therapeutics · 2013Article
- Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Bötzinger complex in mice.The European journal of neuroscience · 2012Article
- Contribution of motoneuron intrinsic properties to fictive motor pattern generation.Journal of neurophysiology · 2011Article
- The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells.Brain : a journal of neurology · 2010Article
- Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
- The effects induced by the sulphonylurea glibenclamide on the neonatal rat spinal cord indicate a novel mechanism to control neuronal excitability and inhibitory neurotransmission.British journal of pharmacology · 2007Article
- Effects of carbenoxolone on heart rhythm, contractility and intracellular calcium in streptozotocin-induced diabetic rat.Molecular and cellular biochemistry · 2006Article
- Glutamate uptake block triggers deadly rhythmic bursting of neonatal rat hypoglossal motoneurons.The Journal of physiology · 2006Article
- Tuning and playing a motor rhythm: how metabotropic glutamate receptors orchestrate generation of motor patterns in the mammalian central nervous system.The Journal of physiology · 2006Review
- Activation of group I metabotropic glutamate receptors depresses recurrent inhibition of motoneurons in the neonatal rat spinal cord in vitro.Experimental brain research · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tongue muscles innervated by the hypoglossal nerves play a crucial role to ensure airway patency and milk suckling in the neonate. Using a slice preparation of the neonatal rat brain, we investigated the electrophysiological characteristics of hypoglossal motoneurones in the attempt to identify certain properties potentially capable of synchronizing motor commands to the tongue. Bath-applied DHPG, a selective agonist of group I metabotropic glutamate receptors (mGluRs), generated persistent, regular electrical oscillations (4-8 Hz) recorded from patch-clamped motoneurones. Under voltage clamp, oscillations were biphasic events, comprising large outward slow currents alternated with fast, repeated inward currents. Electrical oscillations had amplitude and period insensitive to cell membrane potential, and required intact glutamatergic transmission via AMPA receptors. Oscillations were mediated by subtype 1 receptors of group I mGluRs (mGluR1s), and were routinely observed during pharmacological block of glycinergic and GABAergic inhibition, although they could also be recorded in standard saline. Simultaneous recordings from pairs of motoneurones within the same hypoglossal nucleus demonstrated that oscillations were due to their strong electrical coupling and were blocked by the gap junction blocker carbenoxolone. Pacing of slow oscillations apparently depended on the operation of K(ATP) channels in view of the block by tolbutamide or glibenclamide. Under current clamp, oscillations generated more regular spike firing of motoneurones and facilitated glutamatergic excitatory inputs. These data suggest that neonatal motoneurones of the nucleus hypoglossus possess a formerly undisclosed ability to express synchronous electrical oscillations, unveiled by activation of mGluR1s.
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