ArticleCurrent treatment options in neurology2005
Polyneuropathy with Impaired Glucose Tolerance: Implications for Diagnosis and Therapy.
Article in Current treatment options in neurology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Sortilin-Mediated Inhibition of TREK1/2 Channels in Primary Sensory Neurons Promotes Prediabetic Neuropathic Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Longitudinal effects of one-leg standing time on neuropathy outcomes in association with glycemic control in non-elderly patients with type 2 diabetes.Journal of diabetes investigation · 2022Article
- Neuronal Inflammation is Associated with Changes in Epidermal Innervation in High Fat Fed Mice.Frontiers in physiology · 2022Article
- Author's reply: Diagnosing Covid-19 associated Guillain-Barre syndrome.The American journal of emergency medicine · 2021Article
- The effect of 25-hydroxyvitamin D levels on QT interval duration and dispersion in type 2 diabetic patients.Croatian medical journal · 2015Article
- Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats.Investigative ophthalmology & visual science · 2014Article
- Effect of high-fat diet on peripheral neuropathy in C57BL/6 mice.International journal of endocrinology · 2014Article
- Serial anthropometry predicts peripheral nerve dysfunction in a community cohort.Diabetes/metabolism research and reviews · 2013Article
- Article
- Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy.Brain : a journal of neurology · 2011Article
- Phenotypic changes in diabetic neuropathy induced by a high-fat diet in diabetic C57BL/6 mice.Experimental diabetes research · 2011Article
- Disrupted sleep and delayed recovery from chronic peripheral neuropathy are distinct phenotypes in a rat model of metabolic syndrome.Anesthesiology · 2010Article
- p38 mediates mechanical allodynia in a mouse model of type 2 diabetes.Molecular pain · 2010Article
- Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction.Diabetes/metabolism research and reviews · 2010Article
- Nerve growth factor mediates mechanical allodynia in a mouse model of type 2 diabetes.Journal of neuropathology and experimental neurology · 2009Article
- Mechanisms of disease: the oxidative stress theory of diabetic neuropathy.Reviews in endocrine & metabolic disorders · 2008Review
- Diabetic neuropathy: mechanisms to management.Pharmacology & therapeutics · 2008Review
- Standing balance and trunk position sense in impaired glucose tolerance (IGT)-related peripheral neuropathy.Journal of the neurological sciences · 2008Article
- Neuropathy associated with prediabetes: what is new in 2007?Current diabetes reports · 2007Article
- Early diabetic neuropathy: triggers and mechanisms.World journal of gastroenterology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prediabetes is associated with a length-dependent polyneuropathy that typically is sensory predominant and painful. A diagnosis of prediabetes should be sought in patients with otherwise idiopathic sensory-predominant neuropathy by doing a 2-hour oral glucose tolerance test. Fasting plasma glucose of 100 to 125 mg/dL or 2-hour glucose 140 to 199 mg/dL (impaired glucose tolerance) constitutes prediabetes. Most patients with neuropathy associated with prediabetes (NAP) are obese and show metabolic manifestations of insulin resistance, including hyperlipidemia and hypertension. Appropriate treatment addresses hyperglycemia, insulin resistance, and neuropathic pain. Professionally administered individualized diet and exercise counseling (modeled on the Diabetes Prevention Program) has been shown to be more effective than glucose-lowering medications in preventing progression from impaired glucose tolerance to diabetes, and is the mainstay of treatment for all patients with NAP. The goals of this therapy should be a 5% to 7% reduction in weight and an increase to 30 minutes of moderate exercise five times weekly. Patients with prediabetes are at increased risk for myocardial infarction, stroke, and peripheral vascular disease. Therefore, risk reduction with control of hypertension and hyperlipidemia is essential. Neuropathic pain troubles nearly every patient with NAP, and often limits aerobic exercise. No trials have specifically addressed the patient population with NAP, and neuropathic pain treatment closely follows recommendations for diabetic neuropathy. Gabapentin, lamotrigine, and tricyclic antidepressants are well-validated first-line therapies. Adjunctive therapy with opioids, nonsteroidal anti-inflammatory drugs often are necessary. Diet and exercise seem to reduce neuropathic pain in patients with NAP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.