Trial reportWorld journal of gastroenterology2005
Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: comparison with Child-Pugh score and serum bile acid levels.
Trial report in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Breath Test for Monitoring Liver Metabolic Function in Patients With Chronic Liver Disease and Cirrhosis
Use of the BreathID to Assess Hepatic Metabolic Reserve and to Predict Hepatic Decompensation in Patients With Cirrhosis in Need of Liver Transplantation
Pilot Study to Evaluate the Correlation Between ¹³C Methacetin Breath Test (MBT) and HVPG Measurement as a Tool for Identifying Responders to Portal Hypertension Therapy
Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Role of 13C methacetin breath test for non invasive staging of liver fibrosis in patients with chronic hepatitis C.The Indian journal of medical research · 2014Trial
- Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests.International journal of molecular sciences · 2021Review
- Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?International journal of molecular sciences · 2021Review
- (JHEP reports : innovation in hepatology · 2021Article
- Protocols for Mitochondria as the Target of Pharmacological Therapy in the Context of Nonalcoholic Fatty Liver Disease (NAFLD).Methods in molecular biology (Clifton, N.J.) · 2021Review
- Exploring Liver Mitochondrial Function byMethods in molecular biology (Clifton, N.J.) · 2021Article
- A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine.Journal of Zhejiang University. Science. B · 2015Article
- Dynamic carbon 13 breath tests for the study of liver function and gastric emptying.Gastroenterology report · 2015Review
- (13)CO2 breath tests in non-invasive hepatological diagnosis.Przeglad gastroenterologiczny · 2015Review
- Role of the ¹³C-methacetin breath test in the assessment of acute liver injury in a rat model.World journal of gastroenterology · 2014Article
- Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test.PloS one · 2013Article
- C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations.World journal of gastroenterology · 2011Article
- Management of liver cirrhosis between primary care and specialists.World journal of gastroenterology · 2011Article
- Diagnostic value of the C methacetin breath test in various stages of chronic liver disease.Gastroenterology research and practice · 2011Article
- Clinical research on liver reserve function by 13C-phenylalanine breath test in aged patients with chronic liver diseases.BMC geriatrics · 2010Article
- Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL).Hepatology international · 2009Article
- A preliminary study of (13)c-phenylalanine and (13)c-dipeptide breath tests in horses.Journal of equine science · 2009Article
- Prognostic value of (13)C-phenylalanine breath test on predicting survival in patients with chronic liver failure.World journal of gastroenterology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate and compare the clinical usefulness of 13C-phenylalanine and 13C-methacetin breath tests in quantitating functional hepatic mass in patients with chronic liver disease and to further compare these results with those of conventional tests, Child-Pugh score and serum bile acid levels.
methodsOne hundred and forty patients (50 HCV-related chronic hepatitis, 90 liver cirrhosis patients) and 40 matched healthy controls were studied. Both breath test and routine liver test, serum levels of cholic and chenodeoxycholic acid conjugates were evaluated.
resultsMethacetin breath test, expressed as 60 min cumulative percent of oxidation, discriminated the hepatic functional capacity not only between controls and liver disease patients, but also between different categories of chronic liver disease patients. Methacetin breath test was correlated with liver function tests and serum bile acids. Furthermore, methacetin breath test, as well as serum bile acids, were highly predictive of Child-Pugh scores. The diagnostic power of phenylalanine breath test was always less than that of methacetin breath test.
conclusionMethacetin breath test represents a safe and accurate diagnostic tool in the evaluation of hepatic functional mass in chronic liver disease patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.