ArticleWorld journal of gastroenterology2005
Expression patterns of transforming growth factor-beta and its receptors in gastric mucosa of patients with refractory gastric ulcer.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study.World journal of gastroenterology · 2017Trial
- Mucoadhesive chitosan-coated boswellic acids nanoparticles as promising gastroprotective nanoagents via modulation of the RAS/ERK signaling pathway.Discover nano · 2025Article
- Etiology and Therapeutic Strategies for Refractory Peptic Ulcers: A Comprehensive Review.The Korean journal of helicobacter and upper gastrointestinal research · 2025Review
- Article
- Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer.Stem cell research & therapy · 2021Review
- Induction of COX-1, suppression of COX-2 and pro-inflammatory cytokines gene expression by moringa leaves and its aqueous extract in aspirin-induced gastric ulcer rats.Molecular biology reports · 2019Article
- Fruit-Derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms.Frontiers in pharmacology · 2018Review
- Radiologic evaluation of postoperative gastropericardial fistula.Radiology case reports · 2014Article
- Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Gastropericardial fistula as a complication in a refractory gastric ulcer after esophagogastrostomy with gastric pull-up.Yonsei medical journal · 2010Article
- Helicobacter pylori: bacterial factors and the role of cytokines in the immune response.Current microbiology · 2010Article
- Risk factors for gastrointestinal complications in aspirin users: review of clinical and experimental data.Digestive diseases and sciences · 2008Review
- Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms.The American journal of pathology · 2008Article
- TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases.Genes and immunity · 2006Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTransforming growth factor-beta (TGF-beta) plays a regulatory role in tissue repair. In a previous study, we found that TGF-beta and its receptors were expressed in gastric mucosa of patients with well-healed gastric ulcers, as demonstrated by immunohistochemistry. To further characterize the role of TGF-beta and its receptors in repairing gastric ulcers, we investigated the expression patterns of TGF-beta and its receptors in gastric mucosa by in situ hybridization and reverse transcriptase-polymerase chain reaction (RT-PCR).
methodsSeventy-four patients with endoscopically proven gastric ulcers were eligible for participation in this study. All patients had routine biopsies on initial endoscopy and were then treated for 12 wk with an H2 blocker. Repeat endoscopy was then performed. There were 8 patients with poorly healed ulcers, and biopsies were taken from the margin of the residual ulcers. These tissue samples, along with biopsy of gastric mucosa near the original ulcers from 8 randomly selected patients with well-healed ulcers were examined for TGF-beta and TGF-beta receptor II mRNA by RT-PCR and in situ hybridization, as well as immunohistochemistry.
resultsTGF-beta and TGF-beta receptor II were strongly expressed in tissues from patients with well-healed ulcers. Four of the 8 patients with poor healing had low or absent expression of TGF-beta or TGF-beta receptor II mRNA. All cases positive by RT-PCR assay were confirmed by in situ hybridization as well as immunohistochemistry.
conclusionIt is suggested that TGF-beta and its receptors are important for gastric ulcer healing. These results may have implications for further investigation of the healing process and in predicting response to therapy.
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